Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Chromecki, TF; Pummer, K; Mannweiler, S; Zigeuner, R.
Presence and extent of histological tumour necrosis is an adverse prognostic factor in papillary type 1 but not in papillary type 2 renal cell carcinoma.
Histopathology. 2013; 62(2):219-228
Doi: 10.1111/j.1365-2559.2012.04328.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Hutterer Georg
- Mannweiler Sebastian
- Pummer Karl
- Zigeuner Richard
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- Abstract:
- Pichler M, Hutterer G C, Chromecki T F, Pummer K, Mannweiler S & Zigeuner R (2013) Histopathology 62, 219-228 Presence and extent of histological tumour necrosis is an adverse prognostic factor in papillary type 1 but not in papillary type 2 renal cell carcinoma Aims: To date, only limited information is available on the prognostic significance of the presence and extent of histological tumour necrosis with regard to papillary renal cell carcinoma (RCC) types 1 and 2 subclassification. Thus, the aim of this study was to evaluate the prognostic impact of these pathological features on the clinical outcome in papillary subtypes. Methods and results: The influence of histological tumour necrosis on the clinical outcome in 177 patients with papillary RCC was evaluated. For papillary subtype 1, the presence of histological tumour necrosis was an independent negative prognostic factor for disease-free survival (P = 0.039), and a greater extent of necrosis (>20%) was significantly associated with both poor disease-free and overall survival (P = 0.033 and P = 0.041, respectively). Regarding papillary subtype 2, neither the presence nor extent of histological tumour necrosis was a statistically significant negative prognostic factor. Conclusion: Our findings suggest that the presence and extent of histological tumour necrosis are independent prognosticators in papillary RCC subtype 1, but not in papillary subtype 2. Thus, previously reported conflicting data regarding the prognostic impact of tumour necrosis in papillary RCC might be explained, in part, by heterogeneous subtypes.
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- Aged -
- Aged - epidemiology
- Carcinoma, Renal Cell - classification Carcinoma, Renal Cell - diagnosis Carcinoma, Renal Cell - mortality
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Kidney Neoplasms - classification Kidney Neoplasms - diagnosis Kidney Neoplasms - mortality
- Male -
- Middle Aged -
- Necrosis -
- Neoplasm Grading -
- Nephrectomy -
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Find related publications in this database (Keywords)
- papillary histology
- prognosis
- renal cell carcinoma
- tumour necrosis