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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Khalil, M; Enzinger, C; Langkammer, C; Ropele, S; Mader, A; Trentini, A; Vane, ML; Wallner-Blazek, M; Bachmaier, G; Archelos, JJ; Koel-Simmelink, MJ; Blankenstein, MA; Fuchs, S; Fazekas, F; Teunissen, CE.
CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome.
Mult Scler. 2013; 19(4):436-442 Doi: 10.1177/1352458512458010 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Khalil Michael
Co-Autor*innen der Med Uni Graz
Archelos-Garcia Juan-Jose
Bachmaier Gerhard
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Langkammer Christian
Ropele Stefan
Wallner-Blazek Mirja

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Background: Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest. Objective: To study if cerebrospinal fluid (CSF) biomarkers for axonal damage reflect and predict disease progression already in the earliest stages of the disease, that is, in clinically isolated syndrome (CIS). Methods: We assessed CSF levels of neurofilament heavy (NFH), neurofilament light (NFL) and N-acetylaspartate (NAA) in 67 patients with CIS and 18 controls with neuropsychiatric diseases of non-inflammatory aetiology (NC). Patients with CIS underwent baseline magnetic resonance imaging (MRI) at 3T, and a follow-up MRI after 1 year was obtained in 28 of them. Results: Compared with NC, patients with CIS had higher NFH (p=0.05) and NFL (p<0.001) levels. No significant group differences were found for NAA. Patients' NFH levels correlated with physical disability (r=0.304, p<0.05) and with change in brain volume over 1 year of follow-up (r=-0.518, p<0.01) but not with change in T2 lesion load. Conclusion: Our results confirm increased neurofilament levels already in CIS being related to the level of physical disability. The association of NFH levels with brain volume but not lesion volume changes supports the association of these markers with axonal damage.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aspartic Acid - analogs & derivatives
Biological Markers - cerebrospinal fluid
Brain - pathology
Demyelinating Diseases - cerebrospinal fluid
Female -
Humans -
Magnetic Resonance Imaging -
Male -
Neurofilament Proteins - cerebrospinal fluid

Find related publications in this database (Keywords)
Multiple sclerosis
brain atrophy
axonal damage
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