Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Meinitzer, A; Tomaschitz, A; Kienreich, K; Dobnig, H; Schwarz, M; Wagner, D; Drechsler, C; Piswanger-Sölkner, C; März, W; Fahrleitner-Pammer, A.
Associations of homoarginine with bone metabolism and density, muscle strength and mortality: cross-sectional and prospective data from 506 female nursing home patients.
Osteoporos Int. 2013; 24(1):377-381
Doi: 10.1007/s00198-012-1950-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Meinitzer Andreas
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Andrä Michaela
- Dobnig Harald
- Fahrleitner-Pammer Astrid
- Kienreich Katharina
- März Winfried
- Piswanger-Solkner Claudia
- Tomaschitz Andreas
- Wagner Doris
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- Abstract:
- In female nursing home patients, homoarginine was associated with lower bone turnover, higher bone density, lower mortality and, by trend, with muscle strength. Homoarginine, a cationic amino acid, may be relevant for muscusloskeletal health because it inhibits alkaline phosphatases (AP) and is involved in nitric oxide and energy metabolism. We aimed to evaluate whether homoarginine serum concentrations are associated with bone density and metabolism, muscle strength, fractures and mortality. We examined a cohort of female nursing home patients that underwent quantitative bone ultrasound (QUS) measurements and assessments of knee extensor strength. Measurements of serum homoarginine, C-terminal telopeptide cross-links (beta-CTxs) and osteocalcin were also performed at baseline. Thereafter, patients were followed-up with respect to fractures and mortality. Serum homoarginine concentrations were determined in 506 female study participants (mean age: 83.9 +/- 6.0 years). Homoarginine was inversely correlated with beta-CTxs (r = -0.26; p < 0.001) and osteocalcin (r = -0.21; p < 0.001), and these associations remained significant in multiple regression analyses. Multivariate regression analyses showed that homoarginine is significantly associated with calcaneus stiffness (beta coefficient = 0.11; p = 0.020) and by trend with knee extensor strength (beta coefficient = 0.09; p = 0.065). During a mean follow-up time of 27 +/- 8 months, we recorded 119 deaths (23.5%) and 63 fractures (12.5%). In multivariate analyses, homoarginine was associated with significantly reduced risk of mortality and the combined endpoint of fractures and mortality. Whether homoarginine metabolism is critically involved into the pathogenesis of musculoskeletal diseases and fatal events warrants further studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Biological Markers - blood
- Bone Density - physiology
- Bone and Bones - metabolism
- Calcaneus - physiology
- Cross-Sectional Studies -
- Female -
- Fractures, Bone - epidemiology
- Homes for the Aged -
- Homoarginine - blood Homoarginine - deficiency
- Humans -
- Mortality -
- Muscle Strength - physiology
- Muscle, Skeletal - physiology
- Nursing Homes -
- Prognosis -
- Prospective Studies -
- Find related publications in this database (Keywords)
- AGAT
- Amino acids
- Arginine
- GATM
- Homoarginine
- Prospective