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Gewählte Publikation:

Hiendl, L.
Links between adherence behavior and cognition in patients with bipolar disorder and schizophrenia
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp.


Autor*innen der Med Uni Graz:
Bengesser Susanne
Dalkner Nina

Background: Medication-adherence is an essential element for adequate treatment of chronic disorders. Unfortunately, especially in the psychiatric setting, adherence drops to less than 50 % after a maximum of six months. Since cognitive impairment is a core symptom in bipolar and psychotic disorders, with this study we sought to investigate the effects of medication adherence on cognition and global function. Method: PsyCourse, a multicenter longitudinal study in Germany and Austria, was used for linear regression of two broad diagnostic groups with bipolar and psychotic disorders (N = 862). Treatment adherence was evaluated using a self-assessment questionnaire, and a comprehensive neurocognitive test battery was used to assess cognitive performance (trail-making test, verbal digit span, and digit symbol test). Information on the current clinical state was collected using PANSS, YMRS, IDS-C30, and GAF. Results: Adherence, age, medication sum, and diagnostic groups explained a significant proportion of the variance in GAF (R2a= 0.153; F(5, 808) = 25.51, p <.001). Our predictors adjusted for symptoms were statistically significant on cognitive domain “D3 - psychomotor speed” in the bipolar disorder group: (R2a = 0.237; F(6, 328) = 15.88, p <.001) and psychotic disorder group: (R2a = 0.186; F(7, 404) = 12.79, p <.001). Conclusion: Medication adherence does not influence cognition, but global functioning in psychiatric patients. In both, bipolar disorder and psychotic disorder, cognitive function was independent of medication adherence but was influenced by age and sum of taken medication.

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