Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Abramowicz, K.
The effects of smoking in neonates born to mothers with pre-eclamptic risk- A case series study
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 70 [OPEN ACCESS]


Autor*innen der Med Uni Graz:
Goswami Nandu
Pichler Gerhard

Introduction: Maternal smoking during pregnancy and maternal pre-eclampsia have negative effects on neonatal health and are associated with adverse outcomes. These include foetal growth-restriction, pre-term delivery, miscarriage, and neonatal death. Objective: To investigate how smoking influences neonatal parameters of infants born to mothers with pre-eclamptic risk. Methods: The study was conducted as part of the larger “Does nicotine reduce the risk of pre-eclampsia? A prospective study” trial at the Obstetrics Ward at the Medical University of Graz. Three neonates were selected according to the initial study: Neonate of a mother who actively smoked during pregnancy (Case C-S), and neonate of a mother who was a former smoker prior to pregnancy (Case F-S), and neonate of mother who was a non-smoker (Case N-S). Prenatal foetal ultrasound examinations, postnatal neonatal biometry, appearance, -pulse, -grimacing, -activity, -respiration Score (APGAR), venous and arterial umbilical cord blood parameters (UCB), and neonatal changes and adaptation until discharge were compared amongst the three cases. Results: During the 2nd trimester ultrasound examination, increased utero-placental resistance was noted in the actively smoking mother. Nonetheless, prenatal, and postnatal anthropometric parameters were classified as normal in the corresponding neonate, as well as in the other cases. Umbilical cord blood parameters of all cases were within the physiological range. However, the neonate born to the smoking mother displayed the highest differences between arterial and venous cord blood parameters, suggesting increased metabolism. During puerperium, none of the cases developed adverse health conditions. All neonates were discharged in good clinical health. Conclusion: The results of this case series study have shown the potential effect of pre-eclamptic risk and maternal smoking on utero-placental resistance and neonatal cord blood parameters. Regarding the included cases, neonatal health was not affected more severely, when exposed to maternal smoking combined with pre-eclamptic risk. For a better understanding, it is recommended to compare the investigated neonatal parameters in a larger study size.

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