Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Stenzel, C.
Effects of metabolic syndrome and obesity on suicidality in individuals with bipolar disorder.
[ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2021.


Autor*innen der Med Uni Graz:
Dalkner Nina
Unterrainer Human-Friedrich

Background: The prevalence of metabolic syndrome and overweight/obesity is significantly increased in bipolar disorder compared to the general population and is associated with a severe course of illness (including suicidality). The aim of this study was to examine the association between rate of suicidal ideation as well as suicide attempts and metabolic variables (including lipid levels) in individuals with bipolar disorder. Methods: Anthropometric measures, socio-demographic data, suicide history and serum lipid levels were measured in 215 individuals with bipolar disorder (female = 104, male = 111, age range = 18.01 – 82.04 years; mean age = 43.94, SD = 13.68). Metabolic syndrome was calculated using “The International Diabetes Federation” (IDF) criteria. Individuals were divided into normal weight, overweight and obese according to their body mass index. Results: Of the 215 individuals studied, 80.9% reported suicidal ideation, 35.3% reported at least one suicide attempt and 30.7% were diagnosed with metabolic syndrome. Both metabolic syndrome and body mass index were not related to suicide attempts. However, individuals with normal weight had more suicidal ideation than overweight individuals. No difference was found between normal weight and obesity nor overweight and obesity in terms of suicidal ideation. Furthermore, there was no association between suicide attempts or suicidal ideation and serum lipid levels. Conclusion: Contrary to expectations, a difference was found in the BMI categories and suicidal ideation, but not suicide attempts. Serum lipid levels turned out to be not suitable as possible biomarkers for suicidality in individuals with bipolar disorder in our cohort. Special attention should be paid to suicidal ideation and BMI values rather than metabolic syndrome or lipid values when treating suicidal individuals with bipolar disorder.

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