Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Scheipner, L.
THE PLASMA AST/ALT RATIO (DE RITIS) IS AN INDEPENDENT PROGNOSTIC MARKER FOR DISEASE FREE SURVIVAL IN STAGE II AND III COLORECTAL CANCER.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 86
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gerger Armin
- Riedl Jakob
- Altmetrics:
- Abstract:
- Introduction: A high AST/ALT quotient at cancer diagnosis has been associated with poor prognosis in multiple malignancies. In the present study we evaluated the prognostic value of the serum AST/ALT (De Ritis) ratio in a large cohort of non- metastatic CRC patients. Material and Methods: Five-hundred-thirty-six patients with stage II and III CRC as well as available AST/ALT ratio at cancer diagnosis were included in this single-center retrospective analysis. Laboratory data were measured within two weeks before histological tumor diagnosis. Co-Primary endpoints for this analysis were disease free survival (DFS), defined as the time from surgery to disease progression or death and overall survival (OS). Survival analysis was performed by using Kaplan-Meier estimators as well as uni- and multivariable Cox models. Results: In univariate cox regression disease free survival was significantly shorter in patients with an elevated AST/ALT ratio. (HR 1.568, 95% 1.10-2.23, p = 0.012) In multivariable analysis, adjusting for grade, stage and adjuvant chemotherapy, the prognostic association between an elevated AST/ALT ratio and a worse DFS prevailed statistically significant (HR 1.53, 95% 1.05-2.22, p = 0.026). No statistically significant association between the AST/ALT ratio and OS was observed. (HR 1.4, 95% CI 0.89 – 2.22, p = 0.14) Conclusion In this study the serum AST/ALT ratio emerged as a valid prognostic marker for disease free survival in non-metastatic colorectal cancer patients at stage II and III. These findings suggest that the serum AST/ALT ratio might represent a novel and inexpensive prognostic tool to aid in the identification of patients at high risk of recurrent disease.