Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Steiner, B.
Pre-screening for Osteoporosis with Quantitative Ultrasound in Postmenopausal Caucasian Women
Humanmedizin; [ Diplomarbeit ] ; 2018. pp. 23
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Dimai Hans Peter
- Fahrleitner-Pammer Astrid
- Altmetrics:
- Abstract:
- Background: Calcaneal quantitative ultrasound (QUS) is a readily accessible and radiation-free alternative to DXA for assessing BMD. Results obtained from QUS measurement cannot directly be compared to DXA, since these two techniques capture different bone-specific parameters. In order to identify individuals who are likely to have osteoporosis by DXA, device-specific thresholds have to be defined for QUS. Objective: This cross-sectional study evaluated the accuracy of QUS to identify postmenopausal women with osteoporosis defined as a T-score of ≤ -2.5 SD by DXA, and to calculate device-specific cutoff values for the QUS device investigated. Methods: We assessed BMD at the lumbar spine, bilateral femoral neck and total hip sites with DXA, and QUS parameters of the right and left calcaneus in a cohort of 245 postmenopausal treatment-naive women between the age of 40 and 82. Correlation coefficients of BMD and QUS parameters were calculated. Receiver operating characteristic (ROC) curves were generated and areas under the curves (AUC) evaluated. Cutoff values for QUS were defined. Results: Calcaneal QUS’ has the ability to identify postmenopausal women with a T-score ≤ -2.5 at the right hip (AUC = 0.887) and left femoral neck (AUC = 0.824). Cutoff values for the QUS T-score of the right (-1.455) and left (-1.480) calcaneus were defined for screening purposes. Conclusion: This study provides insights into the comparative performance of QUS with DXA. Considering the diagnostic accuracy of this device in comparison with DXA it can be recommended as a pre-screening tool to reduce the number of DXA screenings.