Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Heldt, S; Eigl, S; Prattes, J; Rabensteiner, J; Flick, H; Neumeister, P; Niedrist, T; Ober, J; Obersteiner, S; Prueller, F; Strohmaier, H; Krause, R; Wolfler, A; Hoenigl, M; .
Levels of interleukin-6 and-8 in bronchoalveolar lavage fluid are elevated in haematological patients with invasive pulmonary aspergillosis: A case control study.
MYCOSES. . 2017; 60: 6-7.-51. wiss. Tagung der deutsschrachigen Mykologischen Gesellschaft; AUG 21 - SEPT 2, 2017; Münster.
[Oral Communication]
Web of Science
- Autor*innen der Med Uni Graz:
- Eigl Susanne
- Flick Holger
- Heldt Sven
- Hönigl Martin
- Krause Robert
- Neumeister Peter
- Niedrist Tobias
- Prattes Jürgen
- Prüller Florian
- Rabensteiner Jasmin
- Strohmaier Heimo
- Wölfler Albert
- Altmetrics:
- Abstract:
- Aspergillus spp. have been shown to induce T-helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective of this study was to analyse a bundle of cytokines in serum and bronchoalveolar lavage fluid (BALF) in patients with and without invasive pulmonary aspergillosis (IPA). This nested case-control analysis included 10 patients with probable/proven IPA and 20 matched controls without evidence of IPA, out of a pool of prospectively enrolled (2014-2017) adult cases with underlying haematological malignancies and suspected pulmonary infection. Serum samples were collected within 24hours of BALF sampling. All samples were stored at -70 degrees C for retrospective determination of cytokines. IL-6 and IL-8 were significantly associated with IPA in both serum (P=.011 and P=.028) and BALF (P=.006 and P=.012, respectively), and a trend was observed for serum IL-10 (P=.059). In multivariate conditional logistic regression analysis, IL-10 remained a significant predictor of IPA in serum and IL-8 among BALF cytokines. In conclusion, levels of IL-6 and IL-8 were significantly associated with probable/proven IPA, and a similar trend was observed for serum IL-10. Future cohort studies should determine the diagnostic potential of these cytokines for IPA, and evaluate combinations with other IPA biomarkers/diagnostic tests.