Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langmann, G.
A short historical review about Leksell Gamma Knife Radiosurgery (LGR) for uveal melanomas
SPEKTRUM AUGENHEILKD. 2010; 24(1): 6-10.
Doi: 10.1007/s00717-010-0381-2
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Langmann Gerald
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- Abstract:
- In 1992 during the invention of Leksell Gamma Knife radiosurgery (LGR) at the Gamma Knife center in Graz the rationale for single fraction radiosurgery was not clear. The challange of radiosurgery for uveal melanomas was the need of a single high dose in a radiosensitive globe. Since our start in 1992 we have been steadily lowering the dose from 50 Gy (some of the tumors were treated up to 70 Gy) to 3o Gy thus reducing the incidence of very severe side effects like the neovascular glaucoma to a rate lower than 10%. Meanwhile large ciliary body melanomas or combined diffuse-nodular melanomas with a very large planning treatment volume are now excluded from radiosurgery. Important contributions to the development of radiosurgery for uveal melanomas have been made in Buenos Aires (Zambrano, Bunge and Chinella), Vienna (Zehetmayer), Verona (Marchini), Sheffield (Rennie) and Los Angeles (Logani). In order to come to a final conclusion about the value of single fraction radiosurgery a prospective multi-center randomized study with strict inclusion and exclusion criterions and the same technique (dose planning) seems mandatory thus fulfilling the criterions of Good Clinical Practise (GCP) and Evidence Based Medicine (EBM).
- Find related publications in this database (Keywords)
- Uveal melanoma
- Leksell Gamma Knife radiosurgery (LGR)
- short history
- Medical University Graz