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Langsenlehner, T; Döller, C; Quehenberger, F; Stranzl-Lawatsch, H; Langsenlehner, U; Pummer, K; Kapp, KS.
Treatment results of radiation therapy for muscle-invasive bladder cancer.
Strahlenther Onkol. 2010; 186(4):203-209 Doi: 10.1007/s00066-010-2053-1
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Führende Autor*innen der Med Uni Graz
Langsenlehner Tanja
Co-Autor*innen der Med Uni Graz
Döller Carmen
Kapp Karin S.
Langsenlehner Uwe
Pummer Karl
Quehenberger Franz
Stranzl-Lawatsch Heidi

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To assess local control and survival rates in patients with muscle-invasive bladder cancer treated with external-beam radiotherapy and to investigate prognostic factors. Between 1997 and 2007, 75 patients (male, n = 58; female, n = 17, median age, 74.2 years) with localized transitional cell carcinoma of the bladder (T2, n = 34; T3, n = 32; T4, n = 9) not suitable for radical surgery due to advanced age, comorbidity or inoperability underwent external-beam radiotherapy without simultaneous chemotherapy at the University Clinic of Therapeutic Radiology and Oncology, Medical University of Graz, Austria. A conformal four-field technique was used in all patients to treat the tumor and regional lymph nodes with single daily fractions of 1.8-2 Gy to a total dose of 50-50.4 Gy, followed by a cone-down to encompass the empty bladder which was boosted to 70-70.4 Gy. All patients had undergone transurethral tumor resection prior to radiotherapy which was macroscopically incomplete in 62 patients. Complete response was achieved in 65% of patients. Actuarial 3-year local control and metastases-free survival rates were 52.5% and 63.7%, 3-year local recurrence-free survival rate in complete responders was 71%. In univariate analysis, hydronephrosis, lymph vessel invasion, and macroscopic residual tumor were significantly predictive of disease progression. Hydronephrosis and lymph vessel invasion were also associated with a higher risk of local recurrence. The actuarial 3-year progression-free and overall survival rates were 40.1% and 56.9%, respectively. Radiotherapy is an effective treatment option in terms of local control and survival even in elderly patients with locally advanced bladder cancer not suitable for cystectomy.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - radiotherapy
Carcinoma, Transitional Cell - surgery
Combined Modality Therapy -
Cystoscopy -
Disease-Free Survival -
Dose Fractionation, Radiation -
Female -
Humans -
Lymphatic Irradiation - methods
Lymphatic Metastasis - pathology
Lymphatic Metastasis - radiotherapy
Male -
Neoplasm Invasiveness - pathology
Neoplasm Staging -
Prognosis -
Radiotherapy, Adjuvant -
Radiotherapy, Conformal - methods
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - radiotherapy
Urinary Bladder Neoplasms - surgery

Find related publications in this database (Keywords)
Bladder cancer
External-beam radiotherapy
Local control
Organ preservation
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