Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langsenlehner, T; Döller, C; Quehenberger, F; Stranzl-Lawatsch, H; Langsenlehner, U; Pummer, K; Kapp, KS.
Treatment results of radiation therapy for muscle-invasive bladder cancer.
Strahlenther Onkol. 2010; 186(4):203-209
Doi: 10.1007/s00066-010-2053-1
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- Führende Autor*innen der Med Uni Graz
- Langsenlehner Tanja
- Co-Autor*innen der Med Uni Graz
- Döller Carmen
- Kapp Karin S.
- Langsenlehner Uwe
- Pummer Karl
- Quehenberger Franz
- Stranzl-Lawatsch Heidi
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- Abstract:
- To assess local control and survival rates in patients with muscle-invasive bladder cancer treated with external-beam radiotherapy and to investigate prognostic factors. Between 1997 and 2007, 75 patients (male, n = 58; female, n = 17, median age, 74.2 years) with localized transitional cell carcinoma of the bladder (T2, n = 34; T3, n = 32; T4, n = 9) not suitable for radical surgery due to advanced age, comorbidity or inoperability underwent external-beam radiotherapy without simultaneous chemotherapy at the University Clinic of Therapeutic Radiology and Oncology, Medical University of Graz, Austria. A conformal four-field technique was used in all patients to treat the tumor and regional lymph nodes with single daily fractions of 1.8-2 Gy to a total dose of 50-50.4 Gy, followed by a cone-down to encompass the empty bladder which was boosted to 70-70.4 Gy. All patients had undergone transurethral tumor resection prior to radiotherapy which was macroscopically incomplete in 62 patients. Complete response was achieved in 65% of patients. Actuarial 3-year local control and metastases-free survival rates were 52.5% and 63.7%, 3-year local recurrence-free survival rate in complete responders was 71%. In univariate analysis, hydronephrosis, lymph vessel invasion, and macroscopic residual tumor were significantly predictive of disease progression. Hydronephrosis and lymph vessel invasion were also associated with a higher risk of local recurrence. The actuarial 3-year progression-free and overall survival rates were 40.1% and 56.9%, respectively. Radiotherapy is an effective treatment option in terms of local control and survival even in elderly patients with locally advanced bladder cancer not suitable for cystectomy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Carcinoma, Transitional Cell - mortality
- Carcinoma, Transitional Cell - pathology
- Carcinoma, Transitional Cell - radiotherapy
- Carcinoma, Transitional Cell - surgery
- Combined Modality Therapy -
- Cystoscopy -
- Disease-Free Survival -
- Dose Fractionation, Radiation -
- Female -
- Humans -
- Lymphatic Irradiation - methods
- Lymphatic Metastasis - pathology
- Lymphatic Metastasis - radiotherapy
- Male -
- Neoplasm Invasiveness - pathology
- Neoplasm Staging -
- Prognosis -
- Radiotherapy, Adjuvant -
- Radiotherapy, Conformal - methods
- Urinary Bladder Neoplasms - mortality
- Urinary Bladder Neoplasms - pathology
- Urinary Bladder Neoplasms - radiotherapy
- Urinary Bladder Neoplasms - surgery
- Find related publications in this database (Keywords)
- Bladder cancer
- External-beam radiotherapy
- Local control
- Organ preservation