Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Knechtel, G; Hofmann, G; Gerger, A; Renner, W; Langsenlehner, T; Szkandera, J; Wolf, G; Samonigg, H; Krippl, P; Langsenlehner, U.
Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer.
J Cancer Res Clin Oncol. 2010; 136(12):1813-1819
Doi: 10.1007/s00432-010-0839-2
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- Führende Autor*innen der Med Uni Graz
- Absenger Gudrun
- Gerger Armin
- Hofmann Guenter
- Co-Autor*innen der Med Uni Graz
- Langsenlehner Tanja
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Szkandera Joanna
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- Abstract:
- Women with breast cancer that initially involves local lymph nodes have a higher risk for local recurrence or developing metastases. Recent data suggest that germline polymorphism is a significant, previously unrecognized factor in breast cancer progression and metastasis. We assessed the influence of 16 selected common germline polymorphisms in disease-free survival and overall survival among 216 women diagnosed with lymph node-positive breast cancer. The rare allele of FAS 1377G > A was significantly associated with prolonged disease-free survival (P = 0.012, risk ratio of recurrence (RR) = 0.557, 95% confidence interval (CI) = 0.353-0.878) in univariate analysis. After adjusting for known breast cancer prognostic factors the association remained significant (P = 0.050, RR = 0.500, CI = 0.309-0.809). In overall survival analysis we found a significant association of the FAS 1377G > A (P = 0.040, RR = 0.451, CI = 0.496-1.188) and IL10 592C > A polymorphisms (P = 0.020, RR = 1.707, CI = 1.087-2.680) in the univariate Cox regression. The effect remained statistically significant in the multivariate analysis for the IL10 592C > A polymorphism (P = 0.013, RR 1.841, CI 1.140-2.973). No association was found for MTHFR 677C > T, VEGF 936C > T, CCND1 870G > A, TGFB1 29T > C, FASLG 844C > T, FAS 670A > G, GPB3 825C > T, ITGA2 807C > T, ITGA2 1648G > A, ITGB3 176T > C, MMP1 -1607 1G/2G, MMP3 5A/6A, PTGS2 8473T > C, IL10 592C > A and SULT1A1 638G > A polymorphisms and disease-free survival or overall survival. Our data suggest that the FAS 1377G > A and IL10 592C > A polymorphisms could modify disease-free and overall survival in women with lymph node-positive breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD95 - genetics
- Breast Neoplasms - genetics Breast Neoplasms - pathology
- Disease Progression -
- Disease-Free Survival -
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Genotype -
- Germ-Line Mutation -
- Humans -
- Interleukin-10 - genetics
- Lymph Nodes - pathology
- Lymphatic Metastasis -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Staging -
- Polymorphism, Single Nucleotide -
- Prognosis -
- Find related publications in this database (Keywords)
- Breast cancer
- Prognosis
- Polymorphism
- Lymph node-positive