Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kovacs, G; Maier, R; Aberer, E; Brodmann, M; Scheidl, S; Tröster, N; Hesse, C; Salmhofer, W; Graninger, W; Gruenig, E; Rubin, LJ; Olschewski, H.
Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma.
Am J Respir Crit Care Med. 2009; 180(9):881-886
Doi: 10.1164/rccm.200904-0563OC
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Horst
- Co-Autor*innen der Med Uni Graz
- Aberer Elisabeth
- Brodmann Marianne
- Graninger Winfried
- Hesse Christian
- Maier Robert
- Salmhofer Wolfgang
- Scheidl Stefan
- Tröster Natascha
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Pulmonary arterial hypertension is associated with impaired exercise capacity and decreased survival in patients with scleroderma. Randomized controlled studies showed significant benefit of targeted therapies in patients with a resting mean pulmonary arterial pressure (MPAP) greater than 25 mm Hg. The clinical relevance of pulmonary arterial pressure values in the upper normal range is unknown. To examine the clinical relevance of pulmonary arterial pressure in scleroderma patients. After a noninvasive screening program, 29 patients with systemic sclerosis without significant lung fibrosis and without known pulmonary arterial hypertension underwent right heart catheterization and simultaneous cardiopulmonary exercise test. A six-minute walk distance (6MWD) was determined within 48 hours. A resting MPAP above the median (17 mm Hg) was associated with decreased 6MWD (396 +/- 71 vs. 488 +/- 76 m; P < 0.005) and peak Vo(2) (76 +/- 11% vs. 90 +/- 24%; P = 0.05). Resting pulmonary vascular resistance was inversely correlated with 6MWD (r = 0.45; P < 0.05). At 25 and 50W, MPAP above the median (23 and 28 mm Hg) was associated with decreased 6MWD (P < 0.005; P < 0.0005). At peak exercise, MPAP showed no association with 6MWD or peak Vo(2); however, cardiac index was positively (r = 0.45; P < 0.05) and pulmonary vascular resistance was negatively correlated with 6MWD (r = -0.38; P < 0.05). MPAP and resistance in the upper normal range at rest and moderate exercise are associated with decreased exercise capacity and may indicate early pulmonary vasculopathy in patients with systemic sclerosis. Investigations on the prognostic and therapeutic implications of such borderline findings are warranted. Clinical trial registered with http://www.clinicaltrials.gov (NCT00609349).
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure -
- Cardiac Catheterization -
- Exercise -
- Exercise Test - methods
- Exercise Test - statistics & numerical data
- Exercise Tolerance -
- Humans -
- Middle Aged -
- Rest -
- Scleroderma, Systemic - physiopathology
- Vascular Resistance -
- Walking -
- Find related publications in this database (Keywords)
- exercise capacity
- connective tissue disease
- pulmonary arterial hypertension
- pulmonary arterial pressure increase