Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Wagner, M; Zollner, G; Trauner, M.
New molecular insights into the mechanisms of cholestasis.
J Hepatol. 2009; 51(3): 565-580. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Trauner Michael
Wagner Martin
Zollner Gernot
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Abstract:
Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibility and disease progression in acquired cholestatic disorders. Cholestasis is associated with complex transcriptional and post-transcriptional alterations of hepatobiliary transporters and enzymes participating in bile formation. Ligand-activated nuclear receptors for bile acids and other biliary compounds play a key role in the regulation of genes required for bile formation. Pharmacological interventions in cholestasis may aim at modulating such novel regulatory pathways. This review will summarize the principles of molecular alterations in cholestasis and will give an overview of potential clinical implications.
Find related publications in this database (using NLM MeSH Indexing)
ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology
Bile - metabolism
Cholestasis - chemically induced Cholestasis - genetics Cholestasis - physiopathology
Humans -
Membrane Transport Proteins - genetics Membrane Transport Proteins - physiology
Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology
Signal Transduction - physiology

Find related publications in this database (Keywords)
Cholestasis
Bile acids
Hepatobiliary transporters
Nuclear receptors
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