Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kovacs, G; Berghold, A; Scheidl, S; Olschewski, H.
Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review.
Eur Respir J. 2009; 34(4): 888-894.
Doi: 10.1183/09031936.00145608
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- Führende Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Horst
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Scheidl Stefan
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- Abstract:
- According to current guidelines, pulmonary arterial hypertension (PAH) is diagnosed when mean pulmonary arterial pressure (Ppa) exceeds 25 mmHg at rest or 30 mmHg during exercise. Issues that remain unclear are the classification of Ppa values <25 mmHg and whether Ppa >30 mmHg during exercise is always pathological. We performed a comprehensive literature review and analysed all accessible data obtained by right heart catheter studies from healthy individuals to determine normal Ppa at rest and during exercise. Data on 1,187 individuals from 47 studies in 13 countries were included. Data were stratified for sex, age, geographical origin, body position and exercise level. Ppa at rest was 14.0+/-3.3 mmHg and this value was independent of sex and ethnicity. Resting Ppa was slightly influenced by posture (supine 14.0+/-3.3 mmHg, upright 13.6+/-3.1 mmHg) and age (<30 yrs: 12.8+/- 3.1 mmHg; 30-50 yrs: 12.9+/-3.0 mmHg; > or = 50 yrs: 14.7+/-4.0 mmHg). Ppa during exercise was dependent on exercise level and age. During mild exercise, Ppa was 19.4+/-4.8 mmHg in subjects aged <50 yrs compared with 29.4+/-8.4 mmHg in subjects > or = 50 yrs (p<0.001). In conclusion, while Ppa at rest is virtually independent of age and rarely exceeds 20 mmHg, exercise Ppa is age-related and frequently exceeds 30 mmHg, especially in elderly individuals, which makes it difficult to define normal Ppa values during exercise.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure -
- Exercise -
- Heart Catheterization - standards
- Heart Ventricles -
- Humans -
- Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - physiopathology
- Reference Values -
- Rest -
- Find related publications in this database (Keywords)
- Exercise
- pulmonary artery pressure
- pulmonary hypertension
- reference values
- review
- right heart catheterisation