Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Hofmann, G; Langsenlehner, U; Langsenlehner, T; Yazdani-Biuki, B; Clar, H; Gerger, A; Fuerst, F; Samonigg, H; Krippl, P; Renner, W.
A common hereditary single-nucleotide polymorphism in the gene of FAS and colorectal cancer survival.
J Cell Mol Med. 2009; 13(9B):3699-3702
Doi: 10.1111/j.1582-4934.2009.00720.x
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- Führende Autor*innen der Med Uni Graz
- Hofmann Guenter
- Co-Autor*innen der Med Uni Graz
- Clar Heimo
- Gerger Armin
- Krippl Peter
- Langsenlehner Tanja
- Langsenlehner Uwe
- Moazedi-Fürst Florentine
- Renner Wilfried
- Samonigg Hellmut
- Yazdani-Biuki Babak
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- Abstract:
- Apoptosis plays an important role in embryogenesis, autoimmunity and tumourigenesis. Cell surface death receptors such as TNFRSF6 (FAS) confer a major apoptotic effect. A single-nucleotide polymorphism in the FAS promoter gene, -670A/G, modulates apoptotic signalling and has been related to susceptibility and progression of a variety of cancers. The present study aimed to evaluate the role of this polymorphism for survival of patients with colorectal cancer. We performed a retrospective analysis including 433 patients with histologically confirmed colorectal cancer. A Cox regression model including FAS -670 genotypes, age at diagnosis, tumour grading, primary tumour size, number of lymph nodes examined, number of metastatic lymph nodes, tumour stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate the effect of the FAS genotype on survival. FAS -670A/G genotype frequencies were 24.2% (AA), 46.3% (AG) and 29.5% (GG). Forty-nine patients were excluded from the Cox regression analysis because of missing values. Out of the remaining 384 patients, 69 (18%) died during a follow-up of maximum 10 years. Mean follow-up time was 58 +/- 34 months (median 55 months). Carriers of the homozygous FAS -670GG genotype had a significantly lower survival rate compared with AA/AG genotype carriers (relative risk 1.76, 95% confidence interval 1.08-2.87; P= 0.023). The FAS -670A/G polymorphism may be associated with overall survival time of patients with colorectal cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD95 - genetics
- Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality
- Gene Expression Regulation, Neoplastic -
- Genetic Predisposition to Disease -
- Genotype -
- Heterozygote -
- Homozygote -
- Humans -
- Polymorphism, Genetic -
- Polymorphism, Single Nucleotide -
- Proportional Hazards Models -
- Regression Analysis -
- Retrospective Studies -
- Risk -
- Find related publications in this database (Keywords)
- FAS
- apoptosis
- colorectal cancer
- survival
- polymorphism