Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hofmann, G; Langsenlehner, U; Renner, W; Langsenlehner, T; Yazdani-Biuki, B; Clar, H; Gerger, A; Wehrschuetz, M; Samonigg, H; Krippl, P.
Common single nucleotide polymorphisms in the vascular endothelial growth factor gene and colorectal cancer risk.
J Cancer Res Clin Oncol. 2008; 134(5):591-595
Doi: 10.1007/s00432-007-0322-x
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- Führende Autor*innen der Med Uni Graz
- Hofmann Guenter
- Co-Autor*innen der Med Uni Graz
- Clar Heimo
- Gerger Armin
- Langsenlehner Tanja
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Wehrschütz Martin
- Yazdani-Biuki Babak
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- Abstract:
- Purpose Tumor growth requires the formation of new blood vessels, a phenomenon known as angiogenesis. The most important regulator of angiogenesis is vascular endothelial growth factor (VEGF). Several common polymorphisms in the VEGF-gene have been associated with different VEGF expression, production and plasma levels according to allele status, and influence the risk of developing different types of cancer. Therefore, these variants might be risk factors for colorectal cancer (CRC). Methods In the present case-control study, VEGF genotypes of the +936 C > T, -2578 C > A and -634 G > C polymorphisms were determined in 427 patients with histologically verified CRC and 427 age and sex-matched healthy control subjects. Genotypes were analyzed by a fluorogenic exonuclease assay (TaqMan (TM)). P-value for age at diagnosis was analyzed by student's t test, P-values for tumor characteristics were determined by Pearson's Chi-square test. Threshold for significance was P < 0.05. Results At the time of diagnoses, patients were between 29 and 83 years of age, with a mean age of 61 +/- 10.9 years. VEGF -2578 C > A and VEGF -634 G > C genotype frequencies were similar among patients and controls. Carriers of the 936T-allele were found slightly more frequent among controls (27.2%) than among patients (22.5%), but this difference did not reach statistical significance (P = 0.07). Furthermore, no correlation was found between all these variants and tumor characteristics like size, histological grading, positive regional lymph node metastases or tumor stage. Conclusion We conclude that the investigated polymorphisms are not associated with individual susceptibility to colorectal cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Colorectal Neoplasms - genetics
- Female -
- Genetic Predisposition to Disease -
- Humans -
- Male -
- Middle Aged -
- Neovascularization, Pathologic - genetics
- Polymorphism, Single Nucleotide -
- Risk Factors -
- Tumor Markers, Biological - genetics
- Vascular Endothelial Growth Factor A - genetics
- Find related publications in this database (Keywords)
- colorectal
- cancer
- susceptibility
- VEGF
- polymorphisms