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Liegl, B; Leibl, S; Okcu, M; Beham-Schmid, C; Regauer, S.
Malignant transformation within benign adnexal skin tumours.
Histopathology. 2004; 45(2):162-170 Doi: 10.1111/j.1365-2559.2004.01918.x (- Case Report)
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Führende Autor*innen der Med Uni Graz
Liegl-Atzwanger Bernadette
Regauer Sigrid
Co-Autor*innen der Med Uni Graz
Beham-Schmid Christine
Leibl Sebastian

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AIMS: To report five malignant trichogenic tumours arising in longstanding, previously benign adnexal neoplasms through malignant transformation. Malignant trichogenic adnexal tumours are extremely rare neoplasms. METHODS AND RESULTS: The patients were between 55 years and 79 years of age. Three of the tumours were located on the arms, two on the face. Three of our patients had a history of chronic lymphocytic leukaemia, one patient had a history of colonic adenocarcinoma. The duration of the tumour nodules was reported as between 20 and 40 years before sudden changes occurred. These changes included rapid growth, pain, itching, ulceration and bleeding. Histologically, all tumours were well circumscribed and encapsulated. There was a residual benign tumour component and morphological signs such as bone formation, dystrophic calcification and sclerosis suggesting long duration of the lesions. All patients except for one, who refused further clinical investigation due to her advanced age of 79 years, had an underlying systemic malignancy. CONCLUSIONS: The growth stimulus in these benign adnexal neoplasms resulting in malignant transformation may be attributed to the acquisition of additional genetic events or to immunosuppression due to an underlying neoplastic disease. Therefore, patients with systemic diseases or malignancy should be carefully examined and followed for sudden changes in pre-existing benign cutaneous tumours.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Carcinoma - chemistry
Carcinosarcoma - chemistry
Cell Transformation, Neoplastic - pathology
Female - pathology
Hair Diseases - pathology
Hair Follicle - cytology
Humans - cytology
Male - cytology
Melanocytes - pathology
Middle Aged - pathology
Neoplasms, Adnexal and Skin Appendage - pathology
Pilomatrixoma - chemistry
Skin Neoplasms - pathology

Find related publications in this database (Keywords)
adnexal carcinoma
trichogenic tumours
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