Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
LEBER, KA; BERGLOFF, J; LANGMANN, G; MOKRY, M; SCHROTTNER, O; PENDL, G.
RADIATION SENSITIVITY OF VISUAL AND OCULOMOTOR PATHWAYS
STEREOTACT FUNCT NEUROSURG. Proceedings of the 6th Annual Meeting of the Leksell Gamma Knife Society1995; 64, Suppl 1: 233-238.-Proceedings of the 6th Annual Meeting of the Leksell Gamma Knife Society; MAY 8-11, 1994; Kyoto, JAPAN.
Doi: 10.1159/000098784
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leber Klaus
- Co-Autor*innen der Med Uni Graz
- Langmann Gerald
- Mokry Michael
- Schroettner Oskar
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- Abstract:
- Adverse effects of stereotactic radiosurgery on cranial nerves, especially the optic nerve and its pathways, are not yet sufficiently understood. 29 patients who underwent Gamma Knife radiosurgery for benign skull base tumors were reviewed. In all of them, parts of the visual pathways and/or other cranial nerves in the middle cranial fossa received significant doses of radiation. The dose given was correlated with neuro-ophthalmological findings during a follow-up period of 6-24 months. Cranial nerves III, IV and VI within the cavernous sinus, exposed to a dose from 4.5 to 30 Gy, did not develop signs of a neuropathy. Neither did the trigeminal nerve which received between 5 and 20 Gy. In patients with normal neuro-ophthalmological findings prior to radiosurgery, the visual pathways tolerated a dose between 7.5 to 15 Gy. However, in a group of patients with visual deficits before treatment and where the visual fibers received between 6 and 16.6 Gy, 31% deteriorated afterwards. These results indicate that the visual pathways are more at risk for radiation damage than the other cranial nerves in the region and that they may be even more vulnerable to radiation if prior to radiosurgery their function has been compromised by tumor or previous surgery.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain Neoplasms - surgery
- Cranial Nerve Diseases - etiology
- Humans - etiology
- Oculomotor Nerve - radiation effects
- Radiation Injuries - etiology
- Radiation Tolerance - physiology
- Radiosurgery - adverse effects
- Retrospective Studies - adverse effects
- Visual Pathways - radiation effects
- Find related publications in this database (Keywords)
- STEREOTAXIC RADIOSURGERY
- GAMMA KNIFE
- BRAIN TUMORS
- CRANIAL NERVES
- NEUROPATHY
- VISION
- EYE
- OPTIC NERVE