Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eder, T; Mayer, R; Langsenlehner, U; Renner, W; Krippl, P; Wascher, TC; Pummer, K; Kapp, KS.
Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study.
Eur J Cancer. 2007; 43(3):472-475
Doi: 10.1016/j.ejca.2006.11.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Langsenlehner Tanja
- Co-Autor*innen der Med Uni Graz
- Kapp Karin S.
- Krippl Peter
- Langsenlehner Uwe
- Mayer Ramona
- Pummer Karl
- Renner Wilfried
- Wascher Thomas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Interleukin-10 (IL-10) is a multifunctional cytokine acting as inhibitor of inflammatory and immune responses as well as tumour induced angiogenesis. A common [ATA] haplotype formed by polymorphisms at positions -1082, -819 and -592in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C>A polymorphism. To analyse the role of the IL-10 [ATA] haplotype in prostate cancer we performed a case-control study including 561 prostate cancer patients and 561 male, age-matched, control subjects without malignant disease. The IL-10 -592C>A polymorphism was determined by a 5'-nuclease assay (TaqMan). IL-10 -592 CC, CA and AA genotype frequencies were not significantly different between patients (53.6%, 40.0%, 6.4%) and controls (54.3%, 39.6%, 6.1%; p=0.96). IL-10 genotypes were furthermore not associated with tumour characteristics such as histological grade, T stage, PSA levels at diagnosis, or age at diagnosis. Therefore we conclude that the IL-10 -592C>A promoter polymorphism, tagging the IL-10 low-producer [ATA] haplotype, is not associated with risk for prostate cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Haplotypes - genetics
- Humans -
- Interleukin-10 - genetics
- Male -
- Polymorphism, Genetic - genetics
- Promoter Regions, Genetic - genetics
- Prostatic Neoplasms - genetics
- Risk Factors -
- Find related publications in this database (Keywords)
- prostate cancer
- genetic epidemiology
- interleukin-10
- single nucleotide polymorphisms
- haplotype