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Eder, T; Mayer, R; Langsenlehner, U; Renner, W; Krippl, P; Wascher, TC; Pummer, K; Kapp, KS.
Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study.
Eur J Cancer. 2007; 43(3):472-475 Doi: 10.1016/j.ejca.2006.11.003
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Führende Autor*innen der Med Uni Graz
Langsenlehner Tanja
Co-Autor*innen der Med Uni Graz
Kapp Karin S.
Krippl Peter
Langsenlehner Uwe
Mayer Ramona
Pummer Karl
Renner Wilfried
Wascher Thomas

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Interleukin-10 (IL-10) is a multifunctional cytokine acting as inhibitor of inflammatory and immune responses as well as tumour induced angiogenesis. A common [ATA] haplotype formed by polymorphisms at positions -1082, -819 and -592in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C>A polymorphism. To analyse the role of the IL-10 [ATA] haplotype in prostate cancer we performed a case-control study including 561 prostate cancer patients and 561 male, age-matched, control subjects without malignant disease. The IL-10 -592C>A polymorphism was determined by a 5'-nuclease assay (TaqMan). IL-10 -592 CC, CA and AA genotype frequencies were not significantly different between patients (53.6%, 40.0%, 6.4%) and controls (54.3%, 39.6%, 6.1%; p=0.96). IL-10 genotypes were furthermore not associated with tumour characteristics such as histological grade, T stage, PSA levels at diagnosis, or age at diagnosis. Therefore we conclude that the IL-10 -592C>A promoter polymorphism, tagging the IL-10 low-producer [ATA] haplotype, is not associated with risk for prostate cancer.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Haplotypes - genetics
Humans -
Interleukin-10 - genetics
Male -
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
Prostatic Neoplasms - genetics
Risk Factors -

Find related publications in this database (Keywords)
prostate cancer
genetic epidemiology
single nucleotide polymorphisms
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