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Gewählte Publikation:

Müller, MB; Toschi, N; Kresse, AE; Post, A; Keck, ME.
Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain.
Neuropsychopharmacology. 2000; 23(2): 205-215. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Kresse Adelheid
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Abstract:
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Brain - metabolism
Brain-Derived Neurotrophic Factor - biosynthesis
Cerebral Cortex - metabolism
Cholecystokinin - biosynthesis
Dentate Gyrus - metabolism
Electric Stimulation - instrumentation
Hippocampus - metabolism
Male - metabolism
Neuropeptide Y - biosynthesis
Olfactory Pathways - metabolism
Parietal Lobe - metabolism
RNA, Messenger - biosynthesis
Rats - biosynthesis
Rats, Wistar - biosynthesis
Time - biosynthesis
Transcranial Magnetic Stimulation - therapeutic use

Find related publications in this database (Keywords)
BDNF
CCK
depression
dopamine
neuroprotection
NPY
rTMS
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