Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Timpl, P; Spanagel, R; Sillaber, I; Kresse, A; Reul, JM; Stalla, GK; Blanquet, V; Steckler, T; Holsboer, F; Wurst, W.
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nat Genet. 1998; 19(2): 162-166.
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Kresse Adelheid
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Abstract:
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal from alcohol. Two CRH receptors, Crhr1 and Crhr2, have been identified in the mouse. Crhr1 is highly expressed in the anterior pituitary, neocortex, hippocampus, amygdala and cerebellum, and activation of this receptor stimulates adenylate cyclase. Here we show that in mice lacking Crhr1, the medulla of the adrenal gland is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced. The homozygous mutants exhibit increased exploratory activity and reduced anxiety-related behaviour under both basal conditions and following alcohol withdrawal. Our results demonstrate a key role of the Crhr1 receptor in mediating the stress response and anxiety-related behaviour.
Find related publications in this database (using NLM MeSH Indexing)
Adrenocorticotropic Hormone - blood
Animals - blood
Anxiety - complications
Cells, Cultured - complications
Corticosterone - blood
Ethanol - adverse effects
In Situ Hybridization - adverse effects
Mice - adverse effects
Mice, Knockout - adverse effects
Pituitary Gland - metabolism
Receptors, Corticotropin-Releasing Hormone - deficiency
Stress - genetics
Substance Withdrawal Syndrome - complications

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