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Regauer, S; Liegl, B; Reich, O; Pickel, H; Beham-Schmid, C.
Vulvar lichen sclerosus. The importance of early clinical and histological diagnosis
Hautarzt. 2004; 55(2):158-164 Doi: 10.1007/s00105-003-0645-8
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Führende Autor*innen der Med Uni Graz
Regauer Sigrid
Co-Autor*innen der Med Uni Graz
Beham-Schmid Christine
Liegl-Atzwanger Bernadette
Reich Olaf

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Vulvar lichen sclerosus (LS) is a chronic progressive skin disease of unclear etiology. It is often overlooked in early stages, but progresses to destructive atrophy and is associated with an increased risk of vulvar squamous cell carcinoma. The classical symptoms are pruritus and pain, but they are often not distinctive, so that unclear vulvar problems often lead to a biopsy. The histological picture of early LS is quite different from that of late LS with an atrophic epidermis, markedly sclerotic dermis and stiff dilated vessels. The epidermis in early LS is usually normal with only minor irregularities in the rete pattern. The basement membrane is normal or focally widened, while the edematous dermis has only scattered ectatic vessels. The often dense lichenoid and intraepidermal infiltrate explains the spongiosis and vacuolization of the basal layer keratinocytes. Very early cases may only have a sparse lymphocytic infiltrate and hyper-/parakeratosis of the follicular ostia. Early topical therapy can dampen the progression to atrophic, irreversible LS.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Biopsy -
Carcinoma, Squamous Cell - etiology
Child - etiology
Female - etiology
Humans - etiology
Lichen Sclerosus et Atrophicus - complications
Risk Factors - complications
Skin - pathology
Time Factors - pathology
Vulva - pathology
Vulvar Diseases - complications
Vulvar Lichen Sclerosus - etiology
Vulvar Neoplasms - etiology

Find related publications in this database (Keywords)
lymphocytic infiltrate
malignant potential of LS
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