Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ardjomand, N; Esche, G; Fellner, P; Lindner, S; Panzitt, M; Aigner, R; Langmann, A.
Octreotide scintigraphy for the diagnosis of active Graves' ophthalmopathy
Ophthalmologe. 2003; 100(12):1049-1053
Doi: 10.1007/s00347-003-0807-1
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ardjomand Navid
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Langmann Andrea
- Lindner Susanne
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- Abstract:
- PURPOSE: In this study the diagnostic accuracy of orbital octreotide uptake in patients with presumed active Grave's ophthalmopathy (GO) was evaluated. PATIENTS AND METHODS: A prospective study of 23 patients suffering from GO was carried out. Single photon emission computed tomography (SPECT) images were obtained 4 h after iv injection of 3 mCi 111 indium octreotide. The results were correlated with the patients clinical state during a follow-up of 17.5+/-6 months. RESULTS: Octreotide scintigraphy was positive in 15 and negative in 8 cases, 12 patients with positive octreotide scintigraphy underwent immunosuppressive treatment and showed a clinically positive response with regression of symptoms. In three cases the patients refused immunosuppressive treatment. Patients with negative pathologic orbital octreotide uptake did not undergo any treatment. CONCLUSION: Octreotide scintigraphy is a useful tool to determine the activity state of Graves' ophthalmopathy. Since Graves' ophthalmopathy must be treated in the active phase, octreotide scintigraphy should be performed in subacute cases to facilitate the indications for immunosuppressive treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Data Interpretation, Statistical -
- Female -
- Graves Disease - drug therapy
- Humans - drug therapy
- Immunosuppressive Agents - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Octreotide - analogs and derivatives
- Prospective Studies - analogs and derivatives
- Radiopharmaceuticals - diagnostic use
- Tomography, Emission-Computed, Single-Photon - diagnostic use
- Find related publications in this database (Keywords)
- Graves' ophthalmopathy
- octreotide
- scintigraphy
- somatostatin receptors