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Gewählte Publikation:

Langmann, G; Pendl, G; Müllner, K; Feichtinger, KH; Papaefthymiouaf, G.
High-compared with low-dose radiosurgery for uveal melanomas.
J Neurosurg. 2002; 97(5 Suppl):640-643 Doi: 10.3171/jns.2002.97.supplement_5.0640
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Führende Autor*innen der Med Uni Graz
Langmann Gerald
Co-Autor*innen der Med Uni Graz
Dominikus Karlheinz
Feichtinger Karlheinz
Papaefthymiou Georgios

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OBJECT: The authors compared the results of gamma knife radiosurgery in patients with uveal melanoma who underwent high-dose (treated from 1992-1995) and low-dose irradiation (treated from 1996-2002). METHODS: Thirty-one patients with uveal melanomas were treated with a mean margin dose of 52.1 Gy (high dose) and 33 with a mean dose of 41.5 Gy (low dose), and results were compared between groups. The technical procedure was the same in each group except for radiation dose. In the low-dose group, complete tumor regression (scar formation) occurred in 12% and in the high-dose group in 26%. Partial regression (reduction of the tumor prominence between 50 and 80%) occurred in 81% of the low-dose group and in 58% of the high-dose group. Neovascular glaucoma as a severe complication developed in 9% of the low-dose group and in 48% of the high-dose group. CONCLUSIONS: Reduction of the margin dose from 52.1 to 41.5 Gy appears to achieve the same rate of tumor regression but is associated with a lower rate of severe side effects such as neovascular glaucoma. The follow-up period in the low-dose group, however, was much shorter.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Dose-Response Relationship, Radiation -
Female -
Follow-Up Studies -
Humans -
Male -
Melanoma - surgery
Middle Aged - surgery
Radiosurgery - methods
Treatment Outcome - methods
Uveal Neoplasms - surgery

Find related publications in this database (Keywords)
gamma knife
uveal melanoma
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