Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Liegl, B; Regauer, S.
p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN).
Histopathology. 2006; 48(3):268-274
Doi: 10.1111/j.1365-2559.2005.02321.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Regauer Sigrid
- Co-Autor*innen der Med Uni Graz
- Liegl-Atzwanger Bernadette
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- Abstract:
- AIM: To analyse p53 immunoreactivity in 207 biopsy specimens of lichen sclerosus (LS) and "differentiated vulvar intraepithelial neoplasia" (d-VIN), a postulated precursor lesion for LS-associated vulvar squamous cell carcinoma (SCC), which is characterized by atypical basal keratinocyte proliferations with p53+ basal/suprabasal keratinocyte nuclei. METHODS AND RESULTS: Forty early, 78 classic, 30 hypertrophic vulvar LS, 26 paediatric vulvar and penile LS, 33 vulvar LS-associated SCC and 30 vulvar/penile control specimens were examined for p53 expression and the presence of d-VIN. Nuclear p53 staining was observed in 175/207 LS biopsy specimens. Eighty percent of early and 69% of paediatric LS showed discontinuous/continuous p53 staining in basal keratinocytes. Classic LS showed no p53 staining in 17%, discontinuous basal keratinocyte staining in 20%, continuous basal keratinocyte staining in 58%, basal/suprabasal staining in 5%. Hypertrophic LS revealed basal keratinocyte staining in 32% and basal/suprabasal staining in 61%. p53 staining was associated with sclerosis of blood vessels and dermis, lymphoid infiltrates, vasculitis and hypertrophic LS. d-VIN was seen in 2% of LS alone and in 24% of LS-associated SCC. CONCLUSION: d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Apoptosis -
- Carcinoma in Situ - chemistry
- Carcinoma, Squamous Cell - chemistry
- Cell Proliferation - chemistry
- Diagnosis, Differential - chemistry
- Female - chemistry
- Humans - chemistry
- Immunohistochemistry - chemistry
- Ischemia - diagnosis
- Keratinocytes - chemistry
- Middle Aged - chemistry
- Precancerous Conditions - chemistry
- Tumor Markers, Biological - analysis
- Tumor Suppressor Protein p53 - analysis
- Vulva - blood supply
- Vulvar Lichen Sclerosus - diagnosis
- Vulvar Neoplasms - chemistry
- Find related publications in this database (Keywords)
- hypoxic stress
- ischaemia
- vulvar carcinogenesis
- vulvar intraepithelial neoplasia