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Liegl, B; Regauer, S.
p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN).
Histopathology. 2006; 48(3):268-274 Doi: 10.1111/j.1365-2559.2005.02321.x
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Führende Autor*innen der Med Uni Graz
Regauer Sigrid
Co-Autor*innen der Med Uni Graz
Liegl-Atzwanger Bernadette

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AIM: To analyse p53 immunoreactivity in 207 biopsy specimens of lichen sclerosus (LS) and "differentiated vulvar intraepithelial neoplasia" (d-VIN), a postulated precursor lesion for LS-associated vulvar squamous cell carcinoma (SCC), which is characterized by atypical basal keratinocyte proliferations with p53+ basal/suprabasal keratinocyte nuclei. METHODS AND RESULTS: Forty early, 78 classic, 30 hypertrophic vulvar LS, 26 paediatric vulvar and penile LS, 33 vulvar LS-associated SCC and 30 vulvar/penile control specimens were examined for p53 expression and the presence of d-VIN. Nuclear p53 staining was observed in 175/207 LS biopsy specimens. Eighty percent of early and 69% of paediatric LS showed discontinuous/continuous p53 staining in basal keratinocytes. Classic LS showed no p53 staining in 17%, discontinuous basal keratinocyte staining in 20%, continuous basal keratinocyte staining in 58%, basal/suprabasal staining in 5%. Hypertrophic LS revealed basal keratinocyte staining in 32% and basal/suprabasal staining in 61%. p53 staining was associated with sclerosis of blood vessels and dermis, lymphoid infiltrates, vasculitis and hypertrophic LS. d-VIN was seen in 2% of LS alone and in 24% of LS-associated SCC. CONCLUSION: d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Apoptosis -
Carcinoma in Situ - chemistry
Carcinoma, Squamous Cell - chemistry
Cell Proliferation - chemistry
Diagnosis, Differential - chemistry
Female - chemistry
Humans - chemistry
Immunohistochemistry - chemistry
Ischemia - diagnosis
Keratinocytes - chemistry
Middle Aged - chemistry
Precancerous Conditions - chemistry
Tumor Markers, Biological - analysis
Tumor Suppressor Protein p53 - analysis
Vulva - blood supply
Vulvar Lichen Sclerosus - diagnosis
Vulvar Neoplasms - chemistry

Find related publications in this database (Keywords)
hypoxic stress
vulvar carcinogenesis
vulvar intraepithelial neoplasia
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