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Gewählte Publikation:

Langmann, G; Pendl, G; Klaus-Müllner, G; Papaefthymiou, G; Guss, H.
Gamma knife radiosurgery for uveal melanomas: an 8-year experience.
J Neurosurg. 2000; 93 Suppl 3(2):184-188 Doi: 10.3171/jns.2000.93.supplement_3.0184
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Führende Autor*innen der Med Uni Graz
Langmann Gerald
Co-Autor*innen der Med Uni Graz
Papaefthymiou Georgios

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OBJECT: The authors report their experience using gamma knife radiosurgery (GKS) to treat uveal melanomas. METHODS: Between 1992 and 1998, 60 patients were treated with GKS at a prescription dose between 45 Gy and 80 Gy. The mean diameter of the tumor base was 12.2 mm (range 3-22 mm). The mean height of the tumor prominence was 6.7 mm (range 3-12 mm). The eye was immobilized. The follow-up period ranged from 16 to 94 months. Tumor regression was achieved in 56 (93%) of 60 patients. There were four recurrences followed by enucleation. The severe side effect of neovascular glaucoma developed in 21 (35%) patients in a high-dose group with larger tumors and in proximity to the ciliary body. A reduction in the prescription dose to 40 Gy or less and excluding treatment to tumors near the ciliary body decreased the rate of glaucoma without affecting the rate of tumor control. CONCLUSIONS: Gamma knife radiosurgery at a prescription dose of 45 Gy or more can achieve tumor regression in 85% of the uveal melanomas treated. Neovascular glaucoma can develop in patients when using this dose in tumors near the ciliary body. It is advised that such tumors be avoided and that the prescription dose be reduced to 40 Gy.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Diagnostic Imaging -
Equipment Design -
Eye Enucleation -
Female -
Follow-Up Studies -
Glaucoma, Neovascular - etiology
Humans - etiology
Male - etiology
Melanoma - diagnosis
Middle Aged - diagnosis
Neoplasm Recurrence, Local - diagnosis
Postoperative Complications - etiology
Radiosurgery - instrumentation
Reoperation - instrumentation
Uveal Neoplasms - diagnosis

Find related publications in this database (Keywords)
gamma knife
single fraction
uveal melanoma
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