Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stöger, H; Bauernhofer, T; Kasparek, AK; Schmid, M; Moser, R; Ploner, F; Derstvenscheg, E; Kuss, I; Wilders-Truschnig, M; Steindorfer, P.
Weekly 5-fluorouracil and high-dose folinic acid in combination with epidoxorubicin as first-line therapy in advanced breast cancer: a phase II study.
Cancer Chemother Pharmacol. 1994; 34(1):75-78
Doi: 10.1007/BF00686116
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stöger Herbert
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Kasparek Anne-Katrin
- Ploner Ferdinand
- Samonigg Hellmut
- Schaberl-Moser Renate
- Truschnig-Wilders Martini
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- Abstract:
- A total of 25 patients with advanced breast cancer were treated weekly with i.v. 5-fluorouracil at 350 mg/m2, folinic acid at 500 mg/m2, and epidoxorubicin at 35 mg/m2 as first-line chemotherapy for a maximum of 18 cycles. In all, 24 patients were evaluable for response. Overall, 1 patient achieved a complete response and 11 patients showed a partial response, for an objective response rate of 50%; the median duration of response was 18.3+ months and median survival amounted to 18.8+ months. Side effects were generally mild, with grade II leukopenia occurring in 10 patients and grade III leukopenia, in 1 patient. Other toxicity included nausea and vomiting (82%), diarrhea (48%), stomatitis (48%), and alopecia (92%), all of which were mainly restricted to WHO grades I and II. Our results suggest that leucovorin modulation of 5-fluorouracil can safely be incorporated into combination chemotherapy with epidoxorubicin on the investigated schedule. The observed response rate appears comparable with that obtained with other first-line regimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy
- Drug Administration Schedule -
- Epirubicin - administration & dosage
- Epirubicin - adverse effects
- Female -
- Fluorouracil - administration & dosage
- Fluorouracil - adverse effects
- Humans -
- Leucovorin - administration & dosage
- Leucovorin - adverse effects
- Middle Aged -
- Find related publications in this database (Keywords)
- Leucovorin Fluorouracil
- Epidoxorubicin
- Advanced Breast Cancer
- Weekly Schedule