Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Stöger, H; Bauernhofer, T; Kasparek, AK; Schmid, M; Moser, R; Ploner, F; Derstvenscheg, E; Kuss, I; Wilders-Truschnig, M; Steindorfer, P.
Weekly 5-fluorouracil and high-dose folinic acid in combination with epidoxorubicin as first-line therapy in advanced breast cancer: a phase II study.
Cancer Chemother Pharmacol. 1994; 34(1):75-78 Doi: 10.1007/BF00686116
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Führende Autor*innen der Med Uni Graz
Stöger Herbert
Co-Autor*innen der Med Uni Graz
Bauernhofer Thomas
Kasparek Anne-Katrin
Ploner Ferdinand
Samonigg Hellmut
Schaberl-Moser Renate
Truschnig-Wilders Martini

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A total of 25 patients with advanced breast cancer were treated weekly with i.v. 5-fluorouracil at 350 mg/m2, folinic acid at 500 mg/m2, and epidoxorubicin at 35 mg/m2 as first-line chemotherapy for a maximum of 18 cycles. In all, 24 patients were evaluable for response. Overall, 1 patient achieved a complete response and 11 patients showed a partial response, for an objective response rate of 50%; the median duration of response was 18.3+ months and median survival amounted to 18.8+ months. Side effects were generally mild, with grade II leukopenia occurring in 10 patients and grade III leukopenia, in 1 patient. Other toxicity included nausea and vomiting (82%), diarrhea (48%), stomatitis (48%), and alopecia (92%), all of which were mainly restricted to WHO grades I and II. Our results suggest that leucovorin modulation of 5-fluorouracil can safely be incorporated into combination chemotherapy with epidoxorubicin on the investigated schedule. The observed response rate appears comparable with that obtained with other first-line regimens.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - drug therapy
Drug Administration Schedule -
Epirubicin - administration & dosage
Epirubicin - adverse effects
Female -
Fluorouracil - administration & dosage
Fluorouracil - adverse effects
Humans -
Leucovorin - administration & dosage
Leucovorin - adverse effects
Middle Aged -

Find related publications in this database (Keywords)
Leucovorin Fluorouracil
Advanced Breast Cancer
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