Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wirnsberger, GH; Kleinert, R; Langmann, G; Fuchs, U.
Tumor-Cell Markers in Uveal Melanoma - An Immunohistochemical Study
INT J ONCOL 1997 10: 793-799.
Doi: 10.3892/ijo.10.4.793
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Wirnsberger Gerhard
- Co-Autor*innen der Med Uni Graz
- Kleinert Reinhold
- Langmann Gerald
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- Abstract:
- Monoclonal antibodies to the melanoma-associated antigens HMB-45 and NKI/C3, and for S-100 protein were applied to archival tissue of 43 intraocular melanomas. Tn addition, the expression of the oncoproteins ras-p21 (ras 10) and mutated Ha-ras (E 184) as well as neu/erb-B2 (p185) were immunohistochemically evaluated. Incubation with antibodies to HMB-45 and NKI/C3 revealed consistently moderate to strong staining in all cases. Comparable ras-p21 immunostaining with normal epithelium observed in infiltrating components with a pronounced heterogeneous pattern, was particulary evident in epitheloid tumor cells. In melanomas of the spindle cell type B there was a tendency for patients with neu/erb-B2 positivity to have a worse prognosis. Using the chi-squared test for trend a significant correlation was found between S-100 reactivity, neu/erb-B2 amplification and the clinical outcome.
- Find related publications in this database (Keywords)
- Uveal Melanoma
- Tumor Markers
- Oncogenes
- Prognosis
- S-100 Protein
- Immunocytochemistry