Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
El-Shabrawi, Y; Radner, H; Muellner, K; Langmann, G; Hoefler, G.
The role of UV-radiation in the development of conjunctival malignant melanoma.
Acta Ophthalmol Scand. 1999; 77(1):31-32
Doi: 10.1034/j.1600-0420.1999.770107.x
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- Führende Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Co-Autor*innen der Med Uni Graz
- Höfler Gerald
- Langmann Gerald
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- Abstract:
- PURPOSE: To investigate the possible role of UV-radiation in the development of conjunctival malignant melanoma. N-ras mutations are frequently found in cutaneous melanomas of sun-exposed body areas. UV-radiation is thought to induce mutations in the N-ras gene, that convert these genes into active oncogenes. The presence of N-ras mutations has been considered an indicator for UV-exposure in the development of melanomas on sun-exposed body sides. METHODS: We analyzed six paraffin-embedded conjunctival melanomas for mutations of the N-ras gene. Codons 12, 13 and 61 were amplified using polymerase chain reaction and sequenced. RESULTS: We could not detect point mutations of the N-ras gene in our samples. CONCLUSION: Since we could not find deviations from the wild type sequence in the N-ras gene, our study does not support UV-exposure as being causative in the development of conjunctival melanoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Codon -
- Conjunctival Neoplasms - etiology
- DNA Primers - chemistry
- DNA, Neoplasm - analysis
- Genes, ras - genetics
- Humans - genetics
- Melanoma - etiology
- Neoplasms, Radiation-Induced - etiology
- Point Mutation - etiology
- Polymerase Chain Reaction - etiology
- Risk Factors - etiology
- Ultraviolet Rays - adverse effects
- Find related publications in this database (Keywords)
- Conjunctival Melanoma
- UV-Radiation
- N-Ras Mutations
- Polymerase Chain Reaction