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Gewählte Publikation:

El-Shabrawi, Y; Radner, H; Muellner, K; Langmann, G; Hoefler, G.
The role of UV-radiation in the development of conjunctival malignant melanoma.
Acta Ophthalmol Scand. 1999; 77(1):31-32 Doi: 10.1034/j.1600-0420.1999.770107.x [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
El-Shabrawi Yosuf
Co-Autor*innen der Med Uni Graz
Höfler Gerald
Langmann Gerald

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PURPOSE: To investigate the possible role of UV-radiation in the development of conjunctival malignant melanoma. N-ras mutations are frequently found in cutaneous melanomas of sun-exposed body areas. UV-radiation is thought to induce mutations in the N-ras gene, that convert these genes into active oncogenes. The presence of N-ras mutations has been considered an indicator for UV-exposure in the development of melanomas on sun-exposed body sides. METHODS: We analyzed six paraffin-embedded conjunctival melanomas for mutations of the N-ras gene. Codons 12, 13 and 61 were amplified using polymerase chain reaction and sequenced. RESULTS: We could not detect point mutations of the N-ras gene in our samples. CONCLUSION: Since we could not find deviations from the wild type sequence in the N-ras gene, our study does not support UV-exposure as being causative in the development of conjunctival melanoma.
Find related publications in this database (using NLM MeSH Indexing)
Codon -
Conjunctival Neoplasms - etiology
DNA Primers - chemistry
DNA, Neoplasm - analysis
Genes, ras - genetics
Humans - genetics
Melanoma - etiology
Neoplasms, Radiation-Induced - etiology
Point Mutation - etiology
Polymerase Chain Reaction - etiology
Risk Factors - etiology
Ultraviolet Rays - adverse effects

Find related publications in this database (Keywords)
Conjunctival Melanoma
N-Ras Mutations
Polymerase Chain Reaction
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