Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Klein, M; Rosen, A; Graf, A; Lahousen, M; Kucera, H; Pakisch, B; Vavra, N; Beck, A.
Primary fallopian tube carcinoma--a retrospective survey of 51 cases. Austrian Cooperative Study Group for Fallopian Tube Carcinoma.
Arch Gynecol Obstet. 1994; 255(3):141-146
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Lahousen Manfred
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Abstract:
OBJECTIVE: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I). DESIGN: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were divided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation). RESULTS: Patients of stage 0 had a significantly better prognosis than patients of stage I (p = 0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p = 0.017). CONCLUSION: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - mortality
Adult - mortality
Aged - mortality
Chemotherapy, Adjuvant - mortality
Combined Modality Therapy - mortality
Fallopian Tube Neoplasms - mortality
Fallopian Tubes - pathology
Female - pathology
Follow-Up Studies - pathology
Humans - pathology
Hysterectomy - pathology
Middle Aged - pathology
Neoplasm Invasiveness - pathology
Neoplasm Staging - pathology
Radiotherapy, Adjuvant - pathology
Retrospective Studies - pathology
Survival Rate - pathology

Find related publications in this database (Keywords)
Fallopian Tube Carcinoma
Stage-0
Stage-I
Chemotherapy
Irradiation
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