Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Coombes, BJ; Millischer, V; Batzler, A; Larrabee, B; Hou, L; Papiol, S; Heilbronner, U; Adli, M; Akiyama, K; Akula, N; Amare, AT; Ardau, R; Arias, B; Aubry, JM; Backlund, L; Bauer, M; Baune, BT; Bellivier, F; Benabarre, A; Bengesser, S; Bhattacharjee, AK; Cervantes, P; Chen, HC; Chillotti, C; Cichon, S; Clark, SR; Colom, F; Cruceanu, C; Czerski, PM; Dalkner, N; Degenhardt, F; Del, Zompo, M; DePaulo, JR; Étain, B; Falkai, P; Ferensztajn-Rochowiak, E; Forstner, AJ; Frisen, L; Gard, S; Garnham, JS; Goes, FS; Grigoroiu-Serbanescu, M; Grof, P; Hashimoto, R; Hauser, J; Herms, S; Hoffmann, P; Jamain, S; Jiménez, E; Kahn, JP; Kassem, L; Kato, T; Kelsoe, JR; Kittel-Schneider, S; König, B; Kuo, PH; Kusumi, I; Laje, G; Landén, M; Lavebratt, C; Leboyer, M; Leckband, SG; Maj, M; Manchia, M; Martinsson, L; McCarthy, MJ; McElroy, SL; Mitchell, PB; Mitjans, M; Mondimore, FM; Monteleone, P; Nievergelt, CM; Nöthen, MM; Novák, T; O'Donovan, C; Osby, U; Ozaki, N; Pfennig, A; Pisanu, C; Potash, JB; Reif, A; Reininghaus, E; Rietschel, M; Rouleau, GA; Rybakowski, JK; Schalling, M; Schofield, PR; Schubert, KO; Schweizer, BW; Severino, G; Shekhtman, T; Shilling, PD; Shimoda, K; Simhandl, C; Slaney, CM; Squassina, A; Stamm, T; Stopkova, P; Tortorella, A; Turecki, G; Vieta, E; Witt, SH; Zandi, PP; Fullerton, JM; Alda, M; Frye, MA; Schulze, TG; McMahon, FJ; Biernacka, JM.
Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
Complex Psychiatry. 2021; 7(3-4):80-89
Doi: 10.1159/000519707
[OPEN ACCESS]
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Dalkner Nina
- Reininghaus Eva
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.