Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Jackson, H; Rivero, Calle, I; Broderick, C; Habgood-Coote, D; D'Souza, G; Nichols, S; Vito, O; Gómez-Rial, J; Rivero-Velasco, C; Rodríguez-Núñez, N; Barbeito-Castiñeiras, G; Pérez-Freixo, H; Barreiro-de, Acosta, M; Cunnington, AJ; Herberg, JA; Wright, VJ; Gómez-Carballa, A; Salas, A; Levin, M; Martinon-Torres, F; Kaforou, M, , GEN-COVID, (, study, group;PERFORM, consortium.
Characterisation of the blood RNA host response underpinning severity in COVID-19 patients.
Sci Rep. 2022; 12(1): 12216 Doi: 10.1038/s41598-022-15547-2 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Study Group Mitglieder der Med Uni Graz:
Bauchinger Sebastian
Baumgart Hinrich
Benesch Martin
Binder Alexander
Eber Ernst
Gores Gunther
Haidl Harald
Hauer Almuthe
Keldorfer Markus
Kohlfürst Daniela
Kohlmaier Benno
Krenn Larissa
Leitner Manuel
Löffler Sabine
Niedrist Tobias
Nordberg Gudrun
Pfleger Andreas
Pfurtscheller Klaus
Pilch Heidemarie
Pölz Lena
Rajic Glorija
Roedl Siegfried
Sagmeister Manfred Gerald
Schweintzger Nina
Skrabl-Baumgartner Andrea
Sperl Matthias
Stampfer Laura
Strenger Volker
Till Holger
Trobisch Andreas
Zenz Werner
Zurl Christoph Johann

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Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning infection and disease, as well as severity. We performed whole blood RNA Sequencing of individuals with varying degrees of COVID-19 severity. We used differential expression analysis and pathway enrichment analysis to explore how the blood transcriptome differs between individuals with mild, moderate, and severe COVID-19, performing pairwise comparisons between groups. Increasing COVID-19 severity was characterised by an abundance of inflammatory immune response genes and pathways, including many related to neutrophils and macrophages, in addition to an upregulation of immunoglobulin genes. In this study, for the first time, we show how immunomodulatory treatments commonly administered to COVID-19 patients greatly alter the transcriptome. Our insights into COVID-19 severity reveal the role of immune dysregulation in the progression to severe disease and highlight the need for further research exploring the interplay between SARS-CoV-2 and the inflammatory immune response.
Find related publications in this database (using NLM MeSH Indexing)
COVID-19 - administration & dosage
Humans - administration & dosage
Immunity - administration & dosage
RNA - administration & dosage
SARS-CoV-2 - administration & dosage
Transcriptome - administration & dosage

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