Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jackson, H; Rivero, Calle, I; Broderick, C; Habgood-Coote, D; D'Souza, G; Nichols, S; Vito, O; Gómez-Rial, J; Rivero-Velasco, C; Rodríguez-Núñez, N; Barbeito-Castiñeiras, G; Pérez-Freixo, H; Barreiro-de, Acosta, M; Cunnington, AJ; Herberg, JA; Wright, VJ; Gómez-Carballa, A; Salas, A; Levin, M; Martinon-Torres, F; Kaforou, M, , GEN-COVID, (www.gencovid.eu), study, group;PERFORM, consortium.
Characterisation of the blood RNA host response underpinning severity in COVID-19 patients.
Sci Rep. 2022; 12(1): 12216
Doi: 10.1038/s41598-022-15547-2
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- Study Group Mitglieder der Med Uni Graz:
- Bauchinger Sebastian
- Baumgart Hinrich
- Benesch Martin
- Binder Alexander
- Eber Ernst
- Gores Gunther
- Haidl Harald
- Hauer Almuthe
- Keldorfer Markus
- Kohlfürst Daniela
- Kohlmaier Benno
- Krenn Larissa
- Leitner Manuel
- Löffler Sabine
- Niedrist Tobias
- Nordberg Gudrun
- Pfleger Andreas
- Pfurtscheller Klaus
- Pilch Heidemarie
- Pölz Lena
- Rajic Glorija
- Roedl Siegfried
- Sagmeister Manfred Gerald
- Schweintzger Nina
- Skrabl-Baumgartner Andrea
- Sperl Matthias
- Stampfer Laura
- Strenger Volker
- Till Holger
- Trobisch Andreas
- Zenz Werner
- Zurl Christoph Johann
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- Abstract:
- Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning infection and disease, as well as severity. We performed whole blood RNA Sequencing of individuals with varying degrees of COVID-19 severity. We used differential expression analysis and pathway enrichment analysis to explore how the blood transcriptome differs between individuals with mild, moderate, and severe COVID-19, performing pairwise comparisons between groups. Increasing COVID-19 severity was characterised by an abundance of inflammatory immune response genes and pathways, including many related to neutrophils and macrophages, in addition to an upregulation of immunoglobulin genes. In this study, for the first time, we show how immunomodulatory treatments commonly administered to COVID-19 patients greatly alter the transcriptome. Our insights into COVID-19 severity reveal the role of immune dysregulation in the progression to severe disease and highlight the need for further research exploring the interplay between SARS-CoV-2 and the inflammatory immune response.
- Find related publications in this database (using NLM MeSH Indexing)
- COVID-19 - administration & dosage
- Humans - administration & dosage
- Immunity - administration & dosage
- RNA - administration & dosage
- SARS-CoV-2 - administration & dosage
- Transcriptome - administration & dosage