Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Janisch, M; Adelsmayr, G; Müller, H; Holzinger, A; Janek, E; Talakic, E; Fuchsjäger, M; Schöllnast, H.
Non-contrast-enhanced CT texture analysis of primary and metastatic pancreatic ductal adenocarcinomas: value in assessment of histopathological grade and differences between primary and metastatic lesions.
Abdom Radiol (NY). 2022; 47(12):4151-4159
Doi: 10.1007/s00261-022-03646-7
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- Führende Autor*innen der Med Uni Graz
- Fuchsjäger Michael
- Janisch Michael August Johann
- Co-Autor*innen der Med Uni Graz
- Adelsmayr Gabriel
- Holzinger Andreas
- Janek Elmar
- Müller Heimo
- Schoellnast Helmut
- Talakic Emina
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- Abstract:
- PURPOSE: To evaluate the utility of non-contrast-enhanced CT texture analysis (CTTA) for predicting the histopathological differentiation of pancreatic ductal adenocarcinomas (PDAC) and to compare non-contrast-enhanced CTTA texture features between primary PDAC and hepatic metastases of PDAC. METHODS: This retrospective study included 120 patients with histopathologically confirmed PDAC. Sixty-five patients underwent CT-guided biopsy of primary PDAC, while 55 patients underwent CT-guided biopsy of hepatic PDAC metastasis. All lesions were segmented in non-contrast-enhanced CT scans for CTTA based on histogram analysis, co-occurrence matrix, and run-length matrix. Statistical analysis was conducted for 372 texture features using Mann-Whitney U test, Bonferroni-Holm correction, and receiver operating characteristic (ROC) analysis. A p value < 0.05 was considered statistically significant. RESULTS: Three features were identified that differed significantly between histopathological G2 and G3 primary tumors. Of these, "low gray-level zone emphasis" yielded the largest AUC (0.87 ± 0.04), reaching a sensitivity and specificity of 0.76 and 0.83, respectively, when a cut-off value of 0.482 was applied. Fifty-four features differed significantly between primary and hepatic metastatic PDAC. CONCLUSION: Non-contrast-enhanced CTTA of PDAC identified differences in texture features between primary G2 and G3 tumors that could be used for non-invasive tumor assessment. Extensive differences between the features of primary and metastatic PDAC on CTTA suggest differences in tumor microenvironment.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Retrospective Studies - administration & dosage
- Pancreatic Neoplasms - administration & dosage
- Carcinoma, Pancreatic Ductal - administration & dosage
- Adenocarcinoma - administration & dosage
- Tomography, X-Ray Computed - administration & dosage
- Liver Neoplasms - administration & dosage
- Tumor Microenvironment - administration & dosage
- Find related publications in this database (Keywords)
- Tomography
- X-ray computed
- Pancreas cancer
- Histopathology
- Neoplasm metastases