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Janisch, M; Adelsmayr, G; Müller, H; Holzinger, A; Janek, E; Talakic, E; Fuchsjäger, M; Schöllnast, H.
Non-contrast-enhanced CT texture analysis of primary and metastatic pancreatic ductal adenocarcinomas: value in assessment of histopathological grade and differences between primary and metastatic lesions.
Abdom Radiol (NY). 2022; 47(12):4151-4159 Doi: 10.1007/s00261-022-03646-7 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Fuchsjäger Michael
Janisch Michael August Johann
Co-Autor*innen der Med Uni Graz
Adelsmayr Gabriel
Holzinger Andreas
Janek Elmar
Müller Heimo
Schoellnast Helmut
Talakic Emina

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PURPOSE: To evaluate the utility of non-contrast-enhanced CT texture analysis (CTTA) for predicting the histopathological differentiation of pancreatic ductal adenocarcinomas (PDAC) and to compare non-contrast-enhanced CTTA texture features between primary PDAC and hepatic metastases of PDAC. METHODS: This retrospective study included 120 patients with histopathologically confirmed PDAC. Sixty-five patients underwent CT-guided biopsy of primary PDAC, while 55 patients underwent CT-guided biopsy of hepatic PDAC metastasis. All lesions were segmented in non-contrast-enhanced CT scans for CTTA based on histogram analysis, co-occurrence matrix, and run-length matrix. Statistical analysis was conducted for 372 texture features using Mann-Whitney U test, Bonferroni-Holm correction, and receiver operating characteristic (ROC) analysis. A p value < 0.05 was considered statistically significant. RESULTS: Three features were identified that differed significantly between histopathological G2 and G3 primary tumors. Of these, "low gray-level zone emphasis" yielded the largest AUC (0.87 ± 0.04), reaching a sensitivity and specificity of 0.76 and 0.83, respectively, when a cut-off value of 0.482 was applied. Fifty-four features differed significantly between primary and hepatic metastatic PDAC. CONCLUSION: Non-contrast-enhanced CTTA of PDAC identified differences in texture features between primary G2 and G3 tumors that could be used for non-invasive tumor assessment. Extensive differences between the features of primary and metastatic PDAC on CTTA suggest differences in tumor microenvironment.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Retrospective Studies - administration & dosage
Pancreatic Neoplasms - administration & dosage
Carcinoma, Pancreatic Ductal - administration & dosage
Adenocarcinoma - administration & dosage
Tomography, X-Ray Computed - administration & dosage
Liver Neoplasms - administration & dosage
Tumor Microenvironment - administration & dosage

Find related publications in this database (Keywords)
X-ray computed
Pancreas cancer
Neoplasm metastases
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