Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jakubauskiene, L; Jakubauskas, M; Razanskiene, G; Leber, B; Weber, J; Rohrhofer, L; Ramasauskaite, D; Strupas, K; Stiegler, P; Schemmer, P.
Relaxin and Erythropoietin Significantly Reduce Uterine Tissue Damage during Experimental Ischemia-Reperfusion Injury.
INT J MOL SCI. 2022; 23(13):
Doi: 10.3390/ijms23137120
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- Führende Autor*innen der Med Uni Graz
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Leber Bettina
- Rohrhofer Lisa
- Schemmer Peter
- Weber Jennifer
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- Abstract:
- Successful uterus transplantation, a potential treatment method for women suffering from absolute uterine infertility, is negatively affected by ischemia-reperfusion injury (IRI). The aim of this study is to investigate the protective effect of relaxin (RLX) or/and erythropoietin (EPO) on experimental uterus IRI. Eighty rats, randomly assigned into eight groups (n = 10/group), were pretreated with either saline, 5 μg/kg human relaxin-2, 4000 IU/kg recombinant human erythropoietin or their combination. Ischemia was achieved by clamping the aorta and ovarian arteries for 60 min, following 120 min of reperfusion and tissue sampling. For sham animals, clamping was omitted during surgery. There were no differences in tissue histological score, malondialdehyde (MDA) and superoxide dismutase (SOD) levels, myeloperoxidase (MPO) and TUNEL-positive cell count between all sham-operated rats. Pretreatment with RLX preserved normal tissue morphology, reduced MDA levels, MPO and TUNEL-positive cell count, preserved SOD activity and upregulated NICD and HES1 gene expression when compared to the control group. Pretreatment with EPO reduced MDA levels. In conclusion, pretreatment with RLX, EPO or a combination of both EPO and RLX significantly alleviates uterine tissue damage caused by IRI.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Epoetin Alfa - administration & dosage
- Erythropoietin - pharmacology, therapeutic use
- Female - administration & dosage
- Humans - administration & dosage
- Rats - administration & dosage
- Rats, Wistar - administration & dosage
- Recombinant Proteins - pharmacology
- Relaxin - pharmacology
- Reperfusion Injury - metabolism
- Superoxide Dismutase - metabolism
- Uterus - metabolism
- Find related publications in this database (Keywords)
- transplantation
- uterus
- ischemia-reperfusion injury
- relaxin
- erythropoietin