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Posch-Pertl, L; List, W; Michelitsch, M; Pinter-Hausberger, S; Berisha, B; Posch, F; Kloeckl, L; Renner, W; Weger, M.
Heme oxygenase-1 gene rs2071746 polymorphism in retinal vein occlusion.
Ophthalmic Genet. 2022; 43(5):627-632 Doi: 10.1080/13816810.2022.2092754
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Führende Autor*innen der Med Uni Graz
Posch-Pertl Laura
Co-Autor*innen der Med Uni Graz
Berisha Bujar
List Wolfgang Michael
Michelitsch Monja
Pinter-Hausberger Silke
Posch Florian
Renner Wilfried
Weger Martin

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BACKGROUND: Heme oxygenase-1 (HO-1) is an important cytoprotective enzyme due to its ability to degrade pro-inflammatory heme. The common single nucleotide polymorphism (SNP) rs2071746 on the HMOX1 gene has been associated with HO-1 activity and a variety of cardiovascular diseases. This study was performed to investigate the association between the rs2071746 SNP and retinal vein occlusion (RVO). METHODS: We included 496 RVO patients and 297 control subjects in this case-control study. Genotypes of the rs2071746 polymorphism were determined by TaqMan assays. RESULTS: There was no association between the rs2071746 genotype and the presence of RVO (p = .443). The lack of association was found in all three logistic regression models, namely the dominant (p = .560), the recessive (p = .373) and the co-dominant model (p = .444). The distribution of the rs2071746 genotype was 30% (AA), 51% (AT), and 19% (TT). Baseline characteristics were similar between these genotypes, except for diabetes mellitus, which was less prevalent in the AA genotype (p < .001). CONCLUSION: The rs2071746 polymorphism does not seem to be a major risk factor for the presence of RVO.

Find related publications in this database (Keywords)
Heme oxygenase-1
retinal vein occlusion
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