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Sommer, NG; Hirzberger, D; Paar, L; Berger, L; Ćwieka, H; Schwarze, UY; Herber, V; Okutan, B; Bodey, AJ; Willumeit-Römer, R; Zeller-Plumhoff, B; Löffler, JF; Weinberg, AM.
Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.
Acta Biomater. 2022; 147:427-438 Doi: 10.1016/j.actbio.2022.05.041
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Führende Autor*innen der Med Uni Graz
Sommer Nicole
Weinberg Annelie-Martina
Co-Autor*innen der Med Uni Graz
Berger Leopold
Donnelly Daniela
Herber Valentin
Schwarze Uwe Yacine

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Implant removal is unnecessary for biodegradable magnesium (Mg)-based implants and, therefore, the related risk for implant-induced fractures is limited. Aging, on the other hand, is associated with low bone-turnover and decreased bone mass and density, and thus increased fracture risk. Osteoporosis is accompanied by Mg deficiency, therefore, we hypothesized that Mg-based implants may support bone formation by Mg2+ ion release in an ovariectomy-induced osteoporotic rat model. Hence, we investigated osseointegration and implant degradation of a low-alloyed, degrading Mg-Zn-Ca implant (ZX00) in ovariectomy-induced osteoporotic (Osteo), old healthy (OH), and juvenile healthy (JH) groups of female Sprague Dawley rats via in vivo micro-computed tomography (µCT). For the Osteo rats, we demonstrate diminished trabecular bone already after 8 weeks upon ovariectomy and significantly enhanced implant volume loss, with correspondingly pronounced gas formation, compared to the OH and JH groups. Sclerotic rim development was observed in about half of the osteoporotic rats, suggesting a prevention from foreign-body and osteonecrosis development. Synchrotron radiation-based µCT confirmed lower bone volume fractions in the Osteo group compared to the OH and JH groups. Qualitative histological analysis additionally visualized the enhanced implant degradation in the Osteo group. To date, ZX00 provides an interesting implant material for young and older healthy patients, but it may not be of advantage in pharmacologically untreated osteoporotic conditions. STATEMENT OF SIGNIFICANCE: Magnesium-based implants are promising candidates for treatment of osteoporotic fractures because of their biodegradable, biomechanical, anti-bacterial and bone regenerative properties. Here we investigate magnesium‒zinc‒calcium implant materials in a rat model with ovariectomy-induced osteoporosis (Osteo group) and compare the related osseointegration and implant degradation with the results obtained for old healthy (OH) and juvenile healthy (JH) rats. The work applied an appropriate disease model for osteoporosis and focused in particular on long-term implant degradation for different bone conditions. Enhanced implant degradation and sclerotic rim formation was observed in osteoporotic rats, which illustrates that the setting of different bone models generates significantly modified clinical outcome. It further illustrated that these differences must be taken into account in future biodegradable implant development.
Find related publications in this database (using NLM MeSH Indexing)
Alloys - therapeutic use
Animals - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Magnesium - pharmacology, therapeutic use
Osseointegration - administration & dosage
Osteoporosis - pathology
Ovariectomy - administration & dosage
Rats - administration & dosage
Rats, Sprague-Dawley - administration & dosage
X-Ray Microtomography - administration & dosage
Zinc - therapeutic use

Find related publications in this database (Keywords)
Magnesium-based implants
Histology Micro-computed tomography
Synchrotron radiation
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