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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fandler-Höfler, S; Kneihsl, M; Stauber, RE; Bisping, E; Mangge, H; Wünsch, G; Haidegger, M; Fabisch, L; Hatab, I; Fickert, P; Werring, D; Enzinger, C; Gattringer, T.
Liver Fibrosis-4 index indicates atrial fibrillation in acute ischemic stroke.
Eur J Neurol. 2022; 29(8):2283-2288 Doi: 10.1111/ene.15377 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Fandler-Höfler Simon
Kneihsl Markus
Co-Autor*innen der Med Uni Graz
Bisping Egbert Hubertus
Enzinger Christian
Fabisch Linda
Fickert Peter
Gattringer Thomas
Haidegger Melanie
Hatab Isra
Mangge Harald
Stauber Rudolf
Wünsch Gerit

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BACKGROUND: Non-alcoholic fatty liver disease and particularly liver fibrosis are related to cardiovascular disease and may indicate an increased risk for atrial fibrillation (AF), but this association has not yet been systematically investigated in a cohort of ischemic stroke patients. METHODS: We analyzed data from a prospective single-center study enrolling all consecutive ischemic stroke patients admitted to our stroke unit over a 1-year period. All patients received a thorough etiological workup. For evaluation of liver fibrosis, we determined the Fibrosis-4 (FIB-4) index, a well-established noninvasive liver fibrosis test. Laboratory results were analyzed from a uniform blood sample taken at stroke unit admission. RESULTS: Of 414 included patients (mean age 70.2 years, 57.7% male), FIB-4 indicated advanced liver fibrosis in 92 (22.2%). AF as the underlying stroke mechanism was present in 28.0% (large vessel disease: 25.6%, small vessel disease: 11.4%, cryptogenic: 29.2%). Patients with FIB-4 ≥ 2.67 had higher rates of AF (53.3% vs. 20.8%, p < 0.001), and this association remained significant after correction for established AF risk factors (odds ratio 2.53, 95% confidence interval 1.44-4.46, p = 0.001). FIB-4 was further associated with worse functional outcome 3 months (p < 0.001) and higher mortality 4 years post-stroke (p < 0.02), but these relationships were no longer present after correction for age and initial stroke severity. Moreover, FIB-4 was not associated with long-term recurrent vascular events. CONCLUSIONS: Liver fibrosis assessed by the FIB-4 index is independently associated with AF in acute ischemic stroke patients. Further studies should evaluate whether adding the FIB-4 index to AF risk scores increases their precision.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Atrial Fibrillation - complications, epidemiology
Female - administration & dosage
Humans - administration & dosage
Ischemic Stroke - administration & dosage
Liver Cirrhosis - complications
Male - administration & dosage
Prospective Studies - administration & dosage
Risk Factors - administration & dosage
Stroke - etiology

Find related publications in this database (Keywords)
atrial fibrillation
ischemic stroke
liver fibrosis
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