Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lukenaite, B; Griciune, E; Leber, B; Strupas, K; Stiegler, P; Schemmer, P.
Necroptosis in Solid Organ Transplantation: A Literature Overview.
Int J Mol Sci. 2022; 23(7):
Doi: 10.3390/ijms23073677
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- Führende Autor*innen der Med Uni Graz
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Leber Bettina
- Schemmer Peter
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- Abstract:
- Ischemia-reperfusion injury (IRI) is encountered in various stages during solid organ transplantation (SOT). IRI is known to be a multifactorial inflammatory condition involving hypoxia, metabolic stress, leukocyte extravasation, cellular death (including apoptosis, necrosis and necroptosis) and an activation of immune response. Although the cycle of sterile inflammation during IRI is consistent among different organs, the underlying mechanisms are poorly understood. Receptor-interacting protein kinase 3 (RIPK3) and mixed-lineage kinase domain-like pseudokinase (MLKL) are thought to be crucial in the implementation of necroptosis. Moreover, apart from "silent" apoptotic death, necrosis also causes sterile inflammation-necroinflammation, which is triggered by various damage-associated molecular patterns (DAMPs). Those DAMPs activate the innate immune system, causing local and systemic inflammatory responses, which can result in graft failure. In this overview we summarize knowledge on mechanisms of sterile inflammation processes during SOT with special focus on necroptosis and IRI and discuss protective strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Apoptosis - physiology
- Humans - administration & dosage
- Inflammation - metabolism
- Necroptosis - administration & dosage
- Necrosis - administration & dosage
- Organ Transplantation - adverse effects
- Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
- Reperfusion Injury - metabolism
- Find related publications in this database (Keywords)
- ischemia-reperfusion injury
- necroptosis
- solid organ transplantation
- sterile inflammation