Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Karabelas, E; Longobardi, S; Fuchsberger, J; Razeghi, O; Rodero, C; Strocchi, M; Rajani, R; Haase, G; Plank, G; Niederer, S.
Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models.
IEEE Trans Biomed Eng. 2022; 69(10):3216-3223
Doi: 10.1109/TBME.2022.3163428
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- Co-Autor*innen der Med Uni Graz
- Karabelas Elias
- Plank Gernot
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- Abstract:
- Computational Fluid Dynamics (CFD) is used to assist in designing artificial valves and planning procedures, focusing on local flow features. However, assessing the impact on overall cardiovascular function or predicting longer-term outcomes may requires more comprehensive whole heart CFD models. Fitting such models to patient data requires numerous computationally expensive simulations, and depends on specific clinical measurements to constrain model parameters, hampering clinical adoption. Surrogate models can help to accelerate the fitting process while accounting for the added uncertainty. We create a validated patient-specific four-chamber heart CFD model based on the Navier-Stokes-Brinkman (NSB) equations and test Gaussian Process Emulators (GPEs) as a surrogate model for performing a variance-based global sensitivity analysis (GSA). GSA identified preload as the dominant driver of flow in both the right and left side of the heart, respectively. Left-right differences were seen in terms of vascular outflow resistances, with pulmonary artery resistance having a much larger impact on flow than aortic resistance. Our results suggest that GPEs can be used to identify parameters in personalized whole heart CFD models, and highlight the importance of accurate preload measurements.
- Find related publications in this database (using NLM MeSH Indexing)
- Computer Simulation - administration & dosage
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- Find related publications in this database (Keywords)
- Computational modeling
- Heart
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- Mathematical models
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- Biological system modeling
- Computational fluid dynamics
- Biomedical computing
- finite element analysis
- fluid dynamics
- gaussian processes
- scientific computing