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List, W; Weger, M; Pinter-Hausberger, S; Posch, F; Rabensteiner, J; Pailer, S; Wedrich, A; Posch-Pertl, L.
ENDOTHELIN-1 AS A RISK FACTOR IN RETINAL VEIN OCCLUSION.
Retina. 2022; 42(4):738-743 Doi: 10.1097/IAE.0000000000003374
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Führende Autor*innen der Med Uni Graz
List Wolfgang Michael
Posch-Pertl Laura
Co-Autor*innen der Med Uni Graz
Pailer Sabine
Pinter-Hausberger Silke
Posch Florian
Rabensteiner Jasmin
Wedrich Andreas
Weger Martin
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Abstract:
PURPOSE: Retinal vein occlusion (RVO) risk factors largely coincide with cardiovascular risk factors. Endothelin-1 (ET-1), the most potent vasoconstrictor with proinflammatory properties, is a known cardiovascular risk factor. In this study, we explore the role of serum ET-1 as a potential risk factor for RVO. METHODS: Endothelin-1 serum levels were measured in patients with RVO and control subjects. Samples were measured using the sandwich enzyme-linked immunosorbent assay for the quantitative determination of human big endothelin-1 (Biomedica Group, Austria). RESULTS: The study consisted of 147 RVO patients and 150 control subjects. Median serum ET-1 was significantly higher in RVO patients (0.26 pmol/L; range, 0.19-0.37 pmol/L) compared with control subjects (0.10 pmol/L; range, 0.05-0.22 pmol/L) (P < 0.0001) independent of the occlusion site. The difference remained significant after adjusting for arterial hypertension, diabetes mellitus, history of stroke, history of myocardial infarction, history of venous thromboembolism, glomerular filtration rate, and c-reactive protein. CONCLUSION: In conclusion, our results suggest that ET-1 is a potential risk factor for all types of RVO.

Find related publications in this database (Keywords)
branch retinal vein occlusion
central retinal vein occlusion
endothelin-1
hemicentral retinal vein occlusion
retinal vein occlusion
serum
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