Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Haidegger, M; Kneihsl, M; Niederkorn, K; Deutschmann, H; Mangge, H; Vetta, C; Augustin, M; Wünsch, G; Fandler-Höfler, S; Horner, S; Enzinger, C; Gattringer, T.
Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis.
Sci Rep. 2021; 11(1): 15599 Doi: 10.1038/s41598-021-95135-y [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Haidegger Melanie
Kneihsl Markus
Co-Autor*innen der Med Uni Graz
Augustin Michael
Deutschmann Hannes
Enzinger Christian
Fandler-Höfler Simon
Gattringer Thomas
Horner Susanna
Mangge Harald
Niederkorn Kurt
Vetta Christian
Wünsch Gerit

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In-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been associated with progressive atherosclerosis. We investigated the role of CRP, NLR, PLR and MPV on the development of intracranial ISR and recurrent stroke risk. We retrospectively included all patients who had undergone stenting of symptomatic ICAS at our university hospital between 2005 and 2016. ISR (≥ 50% stenosis) was diagnosed by regular Duplex sonography follow-up studies and confirmed by digital subtraction angiography or computed tomography angiography (mean follow-up duration: 5 years). Laboratory parameters were documented before stenting, at the time of restenosis and at last clinical follow-up. Of 115 patients (mean age: 73 ± 13 years; female: 34%), 38 (33%) developed ISR. The assessed laboratory parameters did not differ between patients with ISR and those without (p > 0.1). While ISR was associated with the occurrence of recurrent ischemic stroke (p = 0.003), CRP, NLR, PLR and MPV were not predictive of such events (p > 0.1). Investigated blood biomarkers of progressive atherosclerosis were not predictive for the occurrence of ISR or recurrent ischemic stroke after ICAS stenting during a 5-year follow-up.

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