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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Maget, A; Dalkner, N; Hamm, C; Bengesser, SA; Fellendorf, FT; Platzer, M; Queissner, R; Birner, A; Lenger, M; Mörkl, S; Kohlhammer-Dohr, A; Rieger, A; Seidl, M; Mendel, L; Färber, T; Wetzlmair, L; Schwalsberger, K; Amberger-Otti, DV; Schöggl, H; Lahousen, T; Leitner-Afschar, B; Unterweger, R; Zelzer, S; Mangge, H; Reininghaus, EZ.
Sex differences in zonulin in affective disorders and associations with current mood symptoms.
J Affect Disord. 2021; 294:441-446 Doi: 10.1016/j.jad.2021.07.021 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Fellendorf Frederike
Maget Alexander
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Dalkner Nina
Hamm Carlo
Kohlhammer-Dohr Alexandra
Lahousen-Luxenberger Theresa
Lenger Melanie
Mangge Harald
Mörkl Sabrina
Platzer Martina
Queissner Robert
Reininghaus Eva
Rieger Alexandra
Schöggl Helmut
Seidl Matthias
Unterweger Renate
Wetzlmair Lisa-Christin
Zelzer Sieglinde

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INTRODUCTION: The bidirectional connection between the brain and the gut within psychiatric entities has gained increasing scientific attention over the last years. As a regulator of intestinal permeability, zonulin acts as a key player on the interface of this interplay. Like several psychiatric disorders, intestinal permeability was associated with inflammation in previous findings. METHODS: In this study we explored differences in zonulin serum levels in currently depressed (n = 55) versus currently euthymic (n = 37) individuals with an affective disorder. Further, we explored sex differences and possible influences on zonulin and affective symptoms like medication, age, body mass index, and smoking status. RESULTS: Serum zonulin was significantly higher in females than in men independent from affective status (z = -2.412, p = .016). More specifically, females in the euthymic subgroup had higher zonulin levels than euthymic men (z = -2.114, p = .035). There was no difference in zonulin serum levels in individuals taking or not taking a specific psychopharmacotherapy. We found no correlation between zonulin serum levels and depression severity. DISCUSSION: Increased serum zonulin levels as a proxy for increased intestinal permeability in women may indicate a state of elevated susceptibility for depression-inducing stimuli.

Find related publications in this database (Keywords)
Affective disorders
Intestinal permeability
Bipolar disorder
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