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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bresesti, I; Avian, A; Bruckner, M; Binder-Heschl, C; Schwaberger, B; Baik-Schneditz, N; Schmölzer, G; Pichler, G; Urlesberger, B.
Impact of bradycardia and hypoxemia on oxygenation in preterm infants requiring respiratory support at birth.
Resuscitation. 2021; 164:62-69 Doi: 10.1016/j.resuscitation.2021.05.004 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Urlesberger Berndt
Co-Autor*innen der Med Uni Graz
Avian Alexander
Baik-Schneditz Nariae
Binder-Heschl Corinna
Krainer Marlies
Pichler Gerhard
Schmölzer Georg
Schwaberger Bernhard Christian

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AIM OF THE STUDY: Analysis of the impact of bradycardia and hypoxemia on the course of cerebral and peripheral oxygenation parameters in preterm infants in need for respiratory support during foetal-to-neonatal transition. METHODS: The first 15 min after birth of 150 preterm neonates in need for respiratory support born at the Division of Neonatology, Graz (Austria) were analyzed. Infants were divided into different groups according to duration of bradycardia exposure (no Bradycardia, brief bradycardia <2 min, and prolonged bradycardia ≥2 min) and to systemic oxygen saturation (SpO2) value at 5 min of life (<80% or ≥80%). Analysis was performed considering the degree of bradycardia alone (step 1) and in association with the presence of hypoxemia (step 2). RESULTS: In step 1, courses of SpO2 differed significantly between bradycardia groups (p = 0.002), while courses of cerebral regional oxygen saturation (crStO2) and cerebral fractional tissue oxygen extraction (cFTOE) were not influenced (p = 0.382 and p = 0.878). In step 2, the additional presence of hypoxemia had a significant impact on the courses of SpO2 (p < 0.001), crStO2 (p < 0.001) and cFTOE (p = 0.045). CONCLUSION: Our study shows that the degree of bradycardia has a significant impact on the course of SpO2 only, but when associated with the additional presence of hypoxemia a significant impact on cerebral oxygenation parameters was seen (crStO2, cFTOE). Furthermore, the additional presence of hypoxemia has a significant impact on FiO2 delivered. Our study emphasizes the importance of HR and SpO2 during neonatal resuscitation, underlining the relevance of hypoxemia during the early transitional phase.
Find related publications in this database (using NLM MeSH Indexing)
Austria - administration & dosage
Bradycardia - etiology
Brain - administration & dosage
Humans - administration & dosage
Hypoxia - etiology
Infant - administration & dosage
Infant, Newborn - administration & dosage
Infant, Premature - administration & dosage
Oxygen - administration & dosage
Resuscitation - administration & dosage
Spectroscopy, Near-Infrared - administration & dosage

Find related publications in this database (Keywords)
Neonatal resuscitation
Degree of bradycardia
Presence of hypoxemia
Preterm infants
Respiratory support
Cerebral oxygen saturation
Cerebral oxygen delivery
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