Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

COVIDSurg Collaborative; GlobalSurg Collaborative.
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Br J Surg. 2021; 108(9):1056-1063 Doi: 10.1093/bjs/znab101 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Study Group Mitglieder der Med Uni Graz:
Andrianakis Alexandros
Belarmino Armin
Brinskelle Petra
Castellani Christoph
Cohnert Tina Ulrike
Fediuk Melanie
Fink Andrea
Holzmeister Clemens
Kahn Judith
Leithner Andreas
Lindenmann Jörg
Lumenta David Benjamin
Michelitsch Birgit
Nischwitz Sebastian Philipp
Puchwein Paul
Schemmer Peter
Singer Georg
Smolle-Juettner Freyja-Maria
Sucher Robert
Till Holger
Wolf Axel

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BACKGROUND: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. METHODS: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. RESULTS: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. CONCLUSION: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent - administration & dosage
Adult - administration & dosage
Aged - administration & dosage
COVID-19 - epidemiology, prevention & control
COVID-19 Vaccines - pharmacology
Comorbidity - administration & dosage
Elective Surgical Procedures - methods
Female - administration & dosage
Humans - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Postoperative Complications - prevention & control
Preoperative Period - administration & dosage
Prospective Studies - administration & dosage
SARS-CoV-2 - immunology
Vaccination - methods
Young Adult - administration & dosage

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