Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ardjomand, N; Komericki, P; Langmann, G; Mattes, D; Moray, M; Scarpatetti, M; El-Shabrawi, Y.
Lymph node metastases arising from uveal melanoma.
Wien Klin Wochenschr. 2005; 117(11-12):433-435
Doi: 10.1007/s00508-005-0329-8
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ardjomand Navid
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Komericki Peter
- Langmann Gerald
- Mattes Dietmar
- Scarpatetti Michael
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- Abstract:
- Since the eye lacks lymphatic vessels, uveal melanomas primarily metastasize hematogenously. Here we report the case of a patient with ciliary body ring melanoma who developed lymph node metastases after a fistulating glaucoma operation. A 40-year-old female Caucasian patient presented with unilateral pigment dispersion. Pigment dispersion glaucoma was diagnosed and since the intraocular pressure could not be managed with topical medication, transscleral cyclophotocoagulation and two trabeculectomies had to be performed. Due to enlargement of the pigmented iris mass and cell deposits in the chamber angle, a ciliary body ring melanoma was presumed and the eye enucleated. Histology confirmed the diagnosis of "ciliary body ring melanoma". Six months after enucleation the patient presented multiple metastases including ipsilateral preauricular and submandibular lymph node metastases. The patient died two months later. Lymph node metastases arising from ciliary body melanomas are very rare. Tumor seeding through the trabeculectomy site into the bleb and then via conjunctival lymphatic vessels might be the crucial factor for this pathway of metastases. Therefore, in cases of unilateral pigment dispersion, malignancy should be excluded before fistulating operations are performed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anterior Chamber - pathology
- Ciliary Body - pathology
- Eye Enucleation - pathology
- Female - pathology
- Follow-Up Studies - pathology
- Glaucoma, Open-Angle - surgery
- Humans - surgery
- Iris - pathology
- Light Coagulation - pathology
- Lymph Nodes - pathology
- Lymphatic Metastasis - pathology
- Melanoma - pathology
- Microscopy - pathology
- Neck - pathology
- Neoplasm Invasiveness - pathology
- Ophthalmoscopy - pathology
- Postoperative Complications - pathology
- Reoperation - pathology
- Trabecular Meshwork - pathology
- Trabeculectomy - pathology
- Uveal Neoplasms - pathology
- Find related publications in this database (Keywords)
- glaucoma
- lymph node
- metastases
- ring melanoma
- trabeculectomy