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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Ardjomand, N; Komericki, P; Langmann, G; Mattes, D; Moray, M; Scarpatetti, M; El-Shabrawi, Y.
Lymph node metastases arising from uveal melanoma.
Wien Klin Wochenschr. 2005; 117(11-12):433-435 Doi: 10.1007/s00508-005-0329-8
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Führende Autor*innen der Med Uni Graz
Ardjomand Navid
Co-Autor*innen der Med Uni Graz
El-Shabrawi Yosuf
Komericki Peter
Langmann Gerald
Mattes Dietmar
Scarpatetti Michael

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Since the eye lacks lymphatic vessels, uveal melanomas primarily metastasize hematogenously. Here we report the case of a patient with ciliary body ring melanoma who developed lymph node metastases after a fistulating glaucoma operation. A 40-year-old female Caucasian patient presented with unilateral pigment dispersion. Pigment dispersion glaucoma was diagnosed and since the intraocular pressure could not be managed with topical medication, transscleral cyclophotocoagulation and two trabeculectomies had to be performed. Due to enlargement of the pigmented iris mass and cell deposits in the chamber angle, a ciliary body ring melanoma was presumed and the eye enucleated. Histology confirmed the diagnosis of "ciliary body ring melanoma". Six months after enucleation the patient presented multiple metastases including ipsilateral preauricular and submandibular lymph node metastases. The patient died two months later. Lymph node metastases arising from ciliary body melanomas are very rare. Tumor seeding through the trabeculectomy site into the bleb and then via conjunctival lymphatic vessels might be the crucial factor for this pathway of metastases. Therefore, in cases of unilateral pigment dispersion, malignancy should be excluded before fistulating operations are performed.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Anterior Chamber - pathology
Ciliary Body - pathology
Eye Enucleation - pathology
Female - pathology
Follow-Up Studies - pathology
Glaucoma, Open-Angle - surgery
Humans - surgery
Iris - pathology
Light Coagulation - pathology
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Melanoma - pathology
Microscopy - pathology
Neck - pathology
Neoplasm Invasiveness - pathology
Ophthalmoscopy - pathology
Postoperative Complications - pathology
Reoperation - pathology
Trabecular Meshwork - pathology
Trabeculectomy - pathology
Uveal Neoplasms - pathology

Find related publications in this database (Keywords)
lymph node
ring melanoma
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