Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reininghaus, EZ; Platzer, M; Kohlhammer-Dohr, A; Hamm, C; Mörkl, S; Bengesser, SA; Fellendorf, FT; Lahousen-Luxenberger, T; Leitner-Afschar, B; Schöggl, H; Amberger-Otti, D; Wurm, W; Queissner, R; Birner, A; Falzberger, VS; Painold, A; Fitz, W; Wagner-Skacel, J; Brunnmayr, M; Rieger, A; Maget, A; Unterweger, R; Schwalsberger, K; Reininghaus, B; Lenger, M; Bastiaanssen, TFS; Dalkner, N.
PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial.
Nutrients. 2020; 12(11):
Doi: 10.3390/nu12113422
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- Führende Autor*innen der Med Uni Graz
- Mörkl Sabrina
- Reininghaus Eva
- Co-Autor*innen der Med Uni Graz
- Amberger-Otti Daniela
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Fellendorf Frederike
- Fitz Werner
- Hamm Carlo
- Kohlhammer-Dohr Alexandra
- Lahousen-Luxenberger Theresa
- Lenger Melanie
- Maget Alexander
- Painold Annamaria
- Platzer Martina
- Queissner Robert
- Reininghaus Bernd
- Rieger Alexandra
- Schöggl Helmut
- Unterweger Renate
- Wagner-Skacel Jolana
- Wurm Walter Ernst
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- Abstract:
- Gut microbiota are suspected to affect brain functions and behavior as well as lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial was to evaluate the effect of probiotic treatment in depressed individuals. Within inpatient care, 82 currently depressed individuals were randomly assigned to either receive a multistrain probiotic plus biotin treatment or biotin plus placebo for 28 days. Clinical symptoms as well as gut microbiome were analyzed at the begin of the study, after one and after four weeks. After 16S rRNA analysis, microbiome samples were bioinformatically explored using QIIME, SPSS, R and Piphillin. Both groups improved significantly regarding psychiatric symptoms. Ruminococcus gauvreauii and Coprococcus 3 were more abundant and β-diversity was higher in the probiotics group after 28 days. KEGG-analysis showed elevated inflammation-regulatory and metabolic pathways in the intervention group. The elevated abundance of potentially beneficial bacteria after probiotic treatment allows speculations on the functionality of probiotic treatment in depressed individuals. Furthermore, the finding of upregulated vitamin B6 and B7 synthesis underlines the connection between the quality of diet, gut microbiota and mental health through the regulation of metabolic functions, anti-inflammatory and anti-apoptotic properties. Concluding, four-week probiotic plus biotin supplementation, in inpatient individuals with a major depressive disorder diagnosis, showed an overall beneficial effect of clinical treatment. However, probiotic intervention compared to placebo only differed in microbial diversity profile, not in clinical outcome measures.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Biodiversity - administration & dosage
- Biotin - pharmacology, therapeutic use
- Cohort Studies - administration & dosage
- Depression - drug therapy, psychology
- Dietary Supplements - administration & dosage
- Female - administration & dosage
- Gastrointestinal Microbiome - drug effects
- Haptoglobins - metabolism
- Humans - administration & dosage
- Male - administration & dosage
- Placebos - administration & dosage
- Principal Component Analysis - administration & dosage
- Probiotics - pharmacology, therapeutic use
- Protein Precursors - metabolism
- Find related publications in this database (Keywords)
- depression
- affective disorders
- gut-brain-axis
- probiotics
- inflammation
- microbiome
- biotin