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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Reininghaus, EZ; Platzer, M; Kohlhammer-Dohr, A; Hamm, C; Mörkl, S; Bengesser, SA; Fellendorf, FT; Lahousen-Luxenberger, T; Leitner-Afschar, B; Schöggl, H; Amberger-Otti, D; Wurm, W; Queissner, R; Birner, A; Falzberger, VS; Painold, A; Fitz, W; Wagner-Skacel, J; Brunnmayr, M; Rieger, A; Maget, A; Unterweger, R; Schwalsberger, K; Reininghaus, B; Lenger, M; Bastiaanssen, TFS; Dalkner, N.
PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial.
Nutrients. 2020; 12(11): Doi: 10.3390/nu12113422 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Mörkl Sabrina
Reininghaus Eva
Co-Autor*innen der Med Uni Graz
Amberger-Otti Daniela
Bengesser Susanne
Birner Armin
Dalkner Nina
Fellendorf Frederike
Fitz Werner
Hamm Carlo
Kohlhammer-Dohr Alexandra
Lahousen-Luxenberger Theresa
Lenger Melanie
Maget Alexander
Painold Annamaria
Platzer Martina
Queissner Robert
Reininghaus Bernd
Rieger Alexandra
Schöggl Helmut
Unterweger Renate
Wagner-Skacel Jolana
Wurm Walter Ernst

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Gut microbiota are suspected to affect brain functions and behavior as well as lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial was to evaluate the effect of probiotic treatment in depressed individuals. Within inpatient care, 82 currently depressed individuals were randomly assigned to either receive a multistrain probiotic plus biotin treatment or biotin plus placebo for 28 days. Clinical symptoms as well as gut microbiome were analyzed at the begin of the study, after one and after four weeks. After 16S rRNA analysis, microbiome samples were bioinformatically explored using QIIME, SPSS, R and Piphillin. Both groups improved significantly regarding psychiatric symptoms. Ruminococcus gauvreauii and Coprococcus 3 were more abundant and β-diversity was higher in the probiotics group after 28 days. KEGG-analysis showed elevated inflammation-regulatory and metabolic pathways in the intervention group. The elevated abundance of potentially beneficial bacteria after probiotic treatment allows speculations on the functionality of probiotic treatment in depressed individuals. Furthermore, the finding of upregulated vitamin B6 and B7 synthesis underlines the connection between the quality of diet, gut microbiota and mental health through the regulation of metabolic functions, anti-inflammatory and anti-apoptotic properties. Concluding, four-week probiotic plus biotin supplementation, in inpatient individuals with a major depressive disorder diagnosis, showed an overall beneficial effect of clinical treatment. However, probiotic intervention compared to placebo only differed in microbial diversity profile, not in clinical outcome measures.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Biodiversity - administration & dosage
Biotin - pharmacology, therapeutic use
Cohort Studies - administration & dosage
Depression - drug therapy, psychology
Dietary Supplements - administration & dosage
Female - administration & dosage
Gastrointestinal Microbiome - drug effects
Haptoglobins - metabolism
Humans - administration & dosage
Male - administration & dosage
Placebos - administration & dosage
Principal Component Analysis - administration & dosage
Probiotics - pharmacology, therapeutic use
Protein Precursors - metabolism

Find related publications in this database (Keywords)
affective disorders
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