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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Müller, N; Fischer, JC; Yabal, M; Haas, T; Poeck, H; Jost, PJ.
XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
Eur J Immunol. 2019; 49(3):504-507 Doi: 10.1002/eji.201847818
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Jost Philipp

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Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bone Marrow Transplantation - methods
Cytokines - metabolism
Genetic Diseases, X-Linked - genetics
Genetic Diseases, X-Linked - metabolism
Genetic Diseases, X-Linked - therapy
Graft Survival -
Graft vs Host Disease - genetics
Graft vs Host Disease - metabolism
Hematopoietic Stem Cell Transplantation - methods
Humans -
Inflammation Mediators - metabolism
Inhibitor of Apoptosis Proteins - deficiency
Inhibitor of Apoptosis Proteins - genetics
Lymphocyte Activation -
Lymphoproliferative Disorders - genetics
Lymphoproliferative Disorders - metabolism
Lymphoproliferative Disorders - therapy
Mice, Inbred C57BL -
Mice, Knockout -
T-Lymphocytes - metabolism
Tissue Donors -
Transplantation, Homologous -

Find related publications in this database (Keywords)
allogeneic HSC transplantation
Graft-versus-host disease
IL-1 beta
mixed lymphocytes reaction
X-linked lymphoproliferative syndrome
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