Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Müller, N; Fischer, JC; Yabal, M; Haas, T; Poeck, H; Jost, PJ.
XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
Eur J Immunol. 2019; 49(3):504-507
Doi: 10.1002/eji.201847818
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Jost Philipp
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- Abstract:
- Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bone Marrow Transplantation - methods
- Cytokines - metabolism
- Genetic Diseases, X-Linked - genetics
- Genetic Diseases, X-Linked - metabolism
- Genetic Diseases, X-Linked - therapy
- Graft Survival -
- Graft vs Host Disease - genetics
- Graft vs Host Disease - metabolism
- Hematopoietic Stem Cell Transplantation - methods
- Humans -
- Inflammation Mediators - metabolism
- Inhibitor of Apoptosis Proteins - deficiency
- Inhibitor of Apoptosis Proteins - genetics
- Lymphocyte Activation -
- Lymphoproliferative Disorders - genetics
- Lymphoproliferative Disorders - metabolism
- Lymphoproliferative Disorders - therapy
- Mice, Inbred C57BL -
- Mice, Knockout -
- T-Lymphocytes - metabolism
- Tissue Donors -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- allogeneic HSC transplantation
- Graft-versus-host disease
- IL-1 beta
- mixed lymphocytes reaction
- X-linked lymphoproliferative syndrome