Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yabal, M; Jost, PJ.
XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle.
Mol Cell Oncol. 2015; 2(1):e964622-e964622
Doi: 10.4161/23723548.2014.964622
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- Führende Autor*innen der Med Uni Graz
- Jost Philipp
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- Abstract:
- There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory syndrome XLP-2. However, it also points to rather unexpected differences between XIAP and the related proteins baculoviral IAP repeat containing 2 and 3 (cIAP1/2).
- Find related publications in this database (Keywords)
- inflammation
- necroptosis
- RIP3
- XIAP
- cell death
- XLP-2
- cIAP1
- cIAP2