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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Jost, PJ; Höckendorf, U.
Necroinflammation emerges as a key regulator of hematopoiesis in health and disease.
Cell Death Differ. 2019; 26(1):53-67 Doi: 10.1038/s41418-018-0194-4 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Jost Philipp

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The hematopoietic system represents an organ system with an exceptional capacity for the production of mature blood cells from a small and mostly quiescent pool of hematopoietic stem cells (HSCs). This extraordinary capacity includes self-renewal but also the propensity to rapidly respond to extrinsic needs, such as acute infections, severe inflammation, and wound healing. In recent years, it became clear that inflammatory signals such as cytokines, chemokine and danger signals from pathogens (PAMPs) or dying cells (DAMPs) impact on HSCs, shaping their proliferation status, lineage bias, and repopulating ability and subsequently increasing the output of mature effector cells. However, inflammatory danger signals negatively impact on the capacity of HSCs to self-renew and to maintain their stem cell capabilities. This is evidenced in conditions of chronic inflammation where bone marrow failure may originate from HSC exhaustion. Even in hematopoietic cancers, inflammatory signals shape the phenotype of the malignant clone as exemplified by necrosome-dependent inflammation elicited during malignant transformation in acute myeloid leukemia. Accordingly, understanding the contribution of inflammatory signals, and specifically necroinflammation, to HSC integrity, HSC long-term functionality, and malignant transformation has attracted substantial research and clinical interest. In this review, we highlight recent developments and open questions at the interplay between inflammation, regulated necrosis, and HSC biology in the context of blood cell development, acute and chronic inflammation, and hematopoietic cancer.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Differentiation -
Cellular Senescence - immunology
Cytokines - blood
Cytokines - immunology
Hematologic Neoplasms - immunology
Hematopoiesis - immunology
Hematopoietic Stem Cells - immunology
Hematopoietic Stem Cells - metabolism
Humans -
Inflammation - blood
Inflammation - immunology
Leukemia - blood
Leukemia - genetics
Leukemia - immunology
Lymphocytes - immunology
Lymphocytes - metabolism
Necrosis - blood
Necrosis - immunology
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